MGP Database

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MGP002122

Ontology/Pathway Information

Entrez Gene ID4862
Gene Nameneuronal PAS domain protein 2
Gene Symbol NPAS2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005634 IDA:UniProtKBCnucleus
GO:0005667 IPI:MGICtranscription factor complex
GO:0001047 ISS:UniProtKBFcore promoter binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0051879 IDA:BHF-UCLFHsp90 protein binding
GO:0046872 IEA:UniProtKB-KWFmetal ion binding
GO:0003700 TAS:ProtIncFsequence-specific DNA binding transcription factor activity
GO:0004871 IEA:InterProFsignal transducer activity
GO:0044255 TAS:ReactomePcellular lipid metabolic process
GO:0006974 IEA:UniProtKB-KWPcellular response to DNA damage stimulus
GO:0007417 TAS:ProtIncPcentral nervous system development
GO:0032922 ISS:UniProtKBPcircadian regulation of gene expression
GO:0042745 IEA:EnsemblPcircadian sleep/wake cycle
GO:0045475 IEA:EnsemblPlocomotor rhythm
GO:0060548 IMP:UniProtKBPnegative regulation of cell death
GO:0045739 IMP:UniProtKBPpositive regulation of DNA repair
GO:0045893 IDA:UniProtKBPpositive regulation of transcription, DNA-templated
GO:0045944 IGI:MGIPpositive regulation of transcription from RNA polymerase II promoter
GO:2001020 IMP:UniProtKBPregulation of response to DNA damage stimulus
GO:0051775 IDA:UniProtKBPresponse to redox state
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111118BMAL1:CLOCK,NPAS2 activates circadian gene expression
REACT_24941Circadian Clock
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_118789REV-ERBA represses gene expression
REACT_118659RORA activates circadian gene expression
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