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MGP002125

Record overview

MGPD IDMGP002125
Gene ID4878
SpeciesHomo sapiens (Human)
Gene Namenatriuretic peptide A
Gene Symbol NPPA
SynonymsANF; ANP; CDD; CDP; PND; ATFB6; ATRST2; CDD-ANF;
Alternate namesnatriuretic peptides A; atriopeptin; cardiodilatin; cardiodilatin-related peptide; cardionatrin; natriuretic peptide precursor A; prepronatriodilatin;
Chromosome1
Map Location1p36.21
SummaryThe protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]
OrthologsView orthologs and multiple alignments for NPPA

Proteins

natriuretic peptides A preproprotein
Refseq ID:NP_006163
Protein GI:23510319
UniProt ID:P01160
mRNA ID:NM_006172
Length:151
RefSeq Status:
MSSFSTTTVSFLLLLAFQLLGQTRANPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQRDGGALGRG
PWDSSDRSALLKSKLRALLTAPRSLRRSSCFGGRMDRIGAQSGLGCNSFRY
 
sig_peptide: 1..25
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2733
peptide sequence: 
MSSFSTTTVSFLLLLAFQLLGQTRA

mat_peptide: 26..92
product: cardiodilatin
calculated_mol_wt: 7368
peptide sequence: 
NPMYNAVSNADLMDFKNLLDHLEEKMPLEDEVVPPQVLSEPNEEAGAALSPLPEVPPWTGEVSPAQR

mat_peptide: 124..151
product: atrial natriuretic factor
calculated_mol_wt: 3083
peptide sequence: 
SLRRSSCFGGRMDRIGAQSGLGCNSFRY
 
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