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MGP002130

Record overview

MGPD IDMGP002130
Gene ID4893
SpeciesHomo sapiens (Human)
Gene Nameneuroblastoma RAS viral (v-ras) oncogene homolog
Gene Symbol NRAS
SynonymsNS6; CMNS; NCMS; ALPS4; N-ras; NRAS1;
Alternate namesGTPase NRas; N-ras protein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog;
Chromosome1
Map Location1p13.2
SummaryThis is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
OrthologsView orthologs and multiple alignments for NRAS

Proteins

GTPase NRas
Refseq ID:NP_002515
Protein GI:4505451
UniProt ID:P01111
mRNA ID:NM_002524
Length:189
RefSeq Status:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQI
KRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM
 
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