MGP Database

MGP002138

Ontology/Pathway Information

Entrez Gene ID	4915
Gene Name	neurotrophic tyrosine kinase, receptor, type 2
Gene Symbol	NTRK2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0009986	IEA:Ensembl	C	cell surface
GO:0005829	IEA:Ensembl	C	cytosol
GO:0043197	IEA:Ensembl	C	dendritic spine
GO:0010008	IEA:UniProtKB-SubCell	C	endosome membrane
GO:0060076	IEA:Ensembl	C	excitatory synapse
GO:0030426	IEA:Ensembl	C	growth cone
GO:0005887	IDA:UniProtKB	C	integral component of plasma membrane
GO:0097481	IEA:Ensembl	C	neuronal postsynaptic density
GO:0043204	IEA:Ensembl	C	perikaryon
GO:0045211	IEA:Ensembl	C	postsynaptic membrane
GO:0048786	IEA:Ensembl	C	presynaptic active zone
GO:0043235	IDA:MGI	C	receptor complex
GO:0005791	IEA:Ensembl	C	rough endoplasmic reticulum
GO:0043195	IEA:Ensembl	C	terminal bouton
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0060175	IMP:UniProtKB	F	brain-derived neurotrophic factor-activated receptor activity
GO:0048403	ISS:UniProtKB	F	brain-derived neurotrophic factor binding
GO:0043121	IDA:UniProtKB	F	neurotrophin binding
GO:0042803	ISS:UniProtKB	F	protein homodimerization activity
GO:0007190	TAS:Reactome	P	activation of adenylate cyclase activity
GO:0007568	IEA:Ensembl	P	aging
GO:0031547	IMP:UniProtKB	P	brain-derived neurotrophic factor receptor signaling pathway
GO:0035584	IEA:Ensembl	P	calcium-mediated signaling using intracellular calcium source
GO:1990090	IEA:Ensembl	P	cellular response to nerve growth factor stimulus
GO:0071356	IEA:Ensembl	P	cellular response to tumor necrosis factor
GO:0021954	ISS:UniProtKB	P	central nervous system neuron development
GO:0021987	ISS:UniProtKB	P	cerebral cortex development
GO:0007623	IEA:Ensembl	P	circadian rhythm
GO:0007631	IEA:Ensembl	P	feeding behavior
GO:0014047	IEA:Ensembl	P	glutamate secretion
GO:0006954	IEA:Ensembl	P	inflammatory response
GO:0007612	ISS:UniProtKB	P	learning
GO:0007616	IEA:Ensembl	P	long-term memory
GO:0060291	IEA:Ensembl	P	long-term synaptic potentiation
GO:0042490	IEA:Ensembl	P	mechanoreceptor differentiation
GO:2000811	IEA:Ensembl	P	negative regulation of anoikis
GO:0043524	ISS:UniProtKB	P	negative regulation of neuron apoptotic process
GO:0007528	IEA:Ensembl	P	neuromuscular junction development
GO:0030182	ISS:UniProtKB	P	neuron differentiation
GO:0001764	ISS:UniProtKB	P	neuron migration
GO:0048011	TAS:Reactome	P	neurotrophin TRK receptor signaling pathway
GO:0048709	IEA:Ensembl	P	oligodendrocyte differentiation
GO:0048935	IEA:Ensembl	P	peripheral nervous system neuron development
GO:0050772	ISS:UniProtKB	P	positive regulation of axonogenesis
GO:0008284	ISS:UniProtKB	P	positive regulation of cell proliferation
GO:0010628	ISS:UniProtKB	P	positive regulation of gene expression
GO:0043410	ISS:UniProtKB	P	positive regulation of MAPK cascade
GO:0010976	ISS:UniProtKB	P	positive regulation of neuron projection development
GO:0014068	ISS:UniProtKB	P	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051968	IEA:Ensembl	P	positive regulation of synaptic transmission, glutamatergic
GO:0046777	ISS:UniProtKB	P	protein autophosphorylation
GO:0050773	IEA:Ensembl	P	regulation of dendrite development
GO:0046928	IEA:Ensembl	P	regulation of neurotransmitter secretion
GO:0051896	IEA:Ensembl	P	regulation of protein kinase B signaling
GO:0032314	ISS:UniProtKB	P	regulation of Rac GTPase activity
GO:0010996	IEA:Ensembl	P	response to auditory stimulus
GO:0009416	IEA:Ensembl	P	response to light stimulus
GO:0046548	IEA:Ensembl	P	retinal rod cell development
GO:0007169	TAS:Reactome	P	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0001570	IEA:Ensembl	P	vasculogenesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_11064	Activation of TRKA receptors
REACT_11046	NGF-independant TRKA activation
REACT_12056	NGF signalling via TRKA from the plasma membrane
REACT_11061	Signalling by NGF
REACT_111102	Signal Transduction