MGP Database

MGP002143

Record overview

MGPD ID	MGP002143
Gene ID	4922
Species	Homo sapiens (Human)
Gene Name	neurotensin
Gene Symbol	NTS
Synonyms	NN; NT; NT/N; NTS1; NMN-125;
Alternate names	neurotensin/neuromedin N; pro-neurotensin/neuromedin;
Chromosome	12
Map Location	12q21
Summary	This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]
Orthologs	View orthologs and multiple alignments for NTS

Proteins

neurotensin/neuromedin N preproprotein

Refseq ID:	NP_006174
Protein GI:	5453816
UniProt ID:	P30990
mRNA ID:	NM_006183
Length:	170
RefSeq Status:

`MMAGMKIQLVCMLLLAFSSWSLCSDSEEEMKALEADFLTNMHTSKISKAHVPSWKMTLLNVCSLVNNLNSPAEETGEVHEEELVARRKLPTALDGFSLEA MLTIYQLHKICHSRAFQHWELIQEDILDTGNDKNGKEEVIKRKIPYILKRQLYENKPRRPYILKRDSYYY`

sig_peptide: 1..23
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2577
peptide sequence: 
MMAGMKIQLVCMLLLAFSSWSLC

mat_peptide: 24..148
product: large neuromedin N
exception: alternative processing
calculated_mol_wt: 14303
peptide sequence: 
SDSEEEMKALEADFLTNMHTSKISKAHVPSWKMTLLNVCSLVNNLNSPAEETGEVHEEELVARRKLPTALDGFSLEAMLTIYQLHKICHSRAFQHWELIQ
EDILDTGNDKNGKEEVIKRKIPYIL

mat_peptide: 144..148
product: neuromedin N
calculated_mol_wt: 618
peptide sequence: 
IPYIL

mat_peptide: 152..163
product: neurotensin
experiment: DESCRIPTION:antimicrobial peptide[PMID: 12074933]
calculated_mol_wt: 1562
peptide sequence: 
LYENKPRRPYIL