MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002164

Ontology/Pathway Information

Entrez Gene ID4988
Gene Nameopioid receptor, mu 1
Gene Symbol OPRM1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0032839 IEA:EnsemblCdendrite cytoplasm
GO:0032590 IEA:EnsemblCdendrite membrane
GO:0005783 TAS:ProtIncCendoplasmic reticulum
GO:0005925 IEA:EnsemblCfocal adhesion
GO:0005794 TAS:ProtIncCGolgi apparatus
GO:0005887 TAS:ProtIncCintegral component of plasma membrane
GO:0045121 IEA:EnsemblCmembrane raft
GO:0043005 IBA:GO_CentralCneuron projection
GO:0043204 IEA:EnsemblCperikaryon
GO:0005886 TAS:ReactomeCplasma membrane
GO:0042383 IEA:EnsemblCsarcolemma
GO:0004979 IMP:UniProtKBFbeta-endorphin receptor activity
GO:0001965 IDA:UniProtKBFG-protein alpha-subunit binding
GO:0031681 IBA:GO_CentralFG-protein beta-subunit binding
GO:0004930 ISS:UniProtKBFG-protein coupled receptor activity
GO:0038047 ISS:UniProtKBFmorphine receptor activity
GO:0042923 IBA:GO_CentralFneuropeptide binding
GO:0005245 ISS:UniProtKBFvoltage-gated calcium channel activity
GO:0002438 IEA:EnsemblPacute inflammatory response to antigenic stimulus
GO:0007191 IEA:EnsemblPadenylate cyclase-activating dopamine receptor signaling pathway
GO:0031635 IEA:EnsemblPadenylate cyclase-inhibiting opioid receptor signaling pathway
GO:0048149 IMP:UniProtKBPbehavioral response to ethanol
GO:0071315 IBA:GO_CentralPcellular response to morphine
GO:0033554 IMP:UniProtKBPcellular response to stress
GO:0007187 TAS:ProtIncPG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007626 IEA:EnsemblPlocomotory behavior
GO:0007194 ISS:UniProtKBPnegative regulation of adenylate cyclase activity
GO:0043951 IDA:UniProtKBPnegative regulation of cAMP-mediated signaling
GO:0008285 TAS:ProtIncPnegative regulation of cell proliferation
GO:0051481 IDA:UniProtKBPnegative regulation of cytosolic calcium ion concentration
GO:0045019 IDA:UniProtKBPnegative regulation of nitric oxide biosynthetic process
GO:0061358 IMP:UniProtKBPnegative regulation of Wnt protein secretion
GO:0007218 IMP:GOCPneuropeptide signaling pathway
GO:0007200 ISS:UniProtKBPphospholipase C-activating G-protein coupled receptor signaling pathway
GO:0032100 IEA:EnsemblPpositive regulation of appetite
GO:0043950 IDA:UniProtKBPpositive regulation of cAMP-mediated signaling
GO:0007204 IDA:UniProtKBPpositive regulation of cytosolic calcium ion concentration
GO:0070374 ISS:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0050769 ISS:UniProtKBPpositive regulation of neurogenesis
GO:0045429 IDA:UniProtKBPpositive regulation of nitric oxide biosynthetic process
GO:0060079 IEA:EnsemblPregulation of excitatory postsynaptic membrane potential
GO:2000310 ISS:UniProtKBPregulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:0051930 IEA:EnsemblPregulation of sensory perception of pain
GO:0042220 IEA:EnsemblPresponse to cocaine
GO:0032094 IEA:EnsemblPresponse to food
GO:0070848 IEA:EnsemblPresponse to growth factor
GO:0032496 IEA:EnsemblPresponse to lipopolysaccharide
GO:0007600 NAS:UniProtKBPsensory perception
GO:0019233 ISS:UniProtKBPsensory perception of pain
GO:0007268 IBA:GO_CentralPsynaptic transmission
GO:0042060 IEA:EnsemblPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_267874Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125Disease
REACT_19231G alpha (i) signalling events
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
REACT_15457G-protein activation
REACT_267615Metabolic disorders of biological oxidation enzymes
REACT_15295Opioid Signalling
REACT_14819Peptide ligand-binding receptors
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
SMP Pathway Links
SMP IDDescription
SMP006793-Methylthiofentanyl Action Pathway
SMP00413Alfentanil Action Pathway
SMP00685Alvimopan Action Pathway
SMP00674Anileridine Action Pathway
SMP00392Benzocaine Action Pathway
SMP00393Bupivacaine Action Pathway
SMP00684Buprenorphine Action Pathway
SMP00414Carfentanil Action Pathway
SMP00394Chloroprocaine Action Pathway
SMP00424Citalopram Action Pathway
SMP00395Cocaine Action Pathway
SMP00405Codeine Action Pathway
SMP00621Codeine Metabolism Pathway
SMP00423Desipramine Action Pathway
SMP00676Dezocine Action Pathway
SMP00396Dibucaine Action Pathway
SMP00689Dihydromorphine Action Pathway
SMP00680Dimethylthiambutene Action Pathway
SMP00675Diphenoxylate Action Pathway
SMP00425Escitalopram Action Pathway
SMP00681Ethylmorphine Action Pathway
SMP00415Fentanyl Action Pathway
SMP00426Fluoxetine Action Pathway
SMP00407Heroin Action Pathway
SMP00623Heroin Metabolism Pathway
SMP00411Hydrocodone Action Pathway
SMP00410Hydromorphone Action Pathway
SMP00422Imipramine Action Pathway
SMP00690Ketobemidone Action Pathway
SMP00683Levallorphan Action Pathway
SMP00397Levobupivacaine Action Pathway
SMP00677Levomethadyl Acetate Action Action Pathway
SMP00673Levorphanol Action Pathway
SMP00398Lidocaine (Local Anaesthetic) Action Pathway
SMP00399Mepivacaine Action Pathway
SMP00408Methadone Action Pathway
SMP00624Methadone Metabolism Pathway
SMP00678Methadyl Acetate Action Pathway
SMP00406Morphine Action Pathway
SMP00622Morphine Metabolism Pathway
SMP00691Nalbuphine Action Pathway
SMP00688Naloxone Action Pathway
SMP00687Naltrexone Action Pathway
SMP00431Nicotine Action Pathway
SMP00400Oxybuprocaine Action Pathway
SMP00409Oxycodone Action Pathway
SMP00412Oxymorphone Action Pathway
SMP00686Pentazocine Action Pathway
SMP00401Prilocaine Action Pathway
SMP00402Procaine Action Pathway
SMP00403Proparacaine Action Pathway
SMP00672Propoxyphene Action Pathway
SMP00416Remifentanil Action Pathway
SMP00404Ropivacaine Action Pathway
SMP00417Sufentanil Action Pathway
SMP00671Tramadol Action Action Pathway
  logo