MGP Database

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MGP002170

Ontology/Pathway Information

Entrez Gene ID4998
Gene Nameorigin recognition complex, subunit 1
Gene Symbol ORC1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0005664 IDA:UniProtKBCnuclear origin of replication recognition complex
GO:0005730 IDA:HPACnucleolus
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:HPACnucleus
GO:0000808 IDA:UniProtKBCorigin recognition complex
GO:0005886 IDA:HPACplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0003682 IEA:InterProFchromatin binding
GO:0003677 TAS:ProtIncFDNA binding
GO:0006260 TAS:ReactomePDNA replication
GO:0006270 TAS:ProtIncPDNA replication initiation
GO:0000082 TAS:ReactomePG1/S transition of mitotic cell cycle
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0000083 TAS:ReactomePregulation of transcription involved in G1/S transition of mitotic cell cycle
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6769Activation of ATR in response to replication stress
REACT_1095Activation of the pre-replicative complex
REACT_567Assembly of the ORC complex at the origin of replication
REACT_2243Assembly of the pre-replicative complex
REACT_1181Association of licensing factors with the pre-replicative complex
REACT_1707CDC6 association with the ORC:origin complex
REACT_1949CDT1 association with the CDC6:ORC:origin complex
REACT_115566Cell Cycle
REACT_1538Cell Cycle Checkpoints
REACT_152Cell Cycle, Mitotic
REACT_383DNA Replication
REACT_734DNA Replication Pre-Initiation
REACT_1321E2F-enabled inhibition of pre-replication complex formation
REACT_471E2F mediated regulation of DNA replication
REACT_683G1/S-Specific Transcription
REACT_1783G1/S Transition
REACT_828G2/M Checkpoints
REACT_1725M/G1 Transition
REACT_21267Mitotic G1-G1/S phases
REACT_1156Orc1 removal from chromatin
REACT_829Regulation of DNA replication
REACT_207Removal of licensing factors from origins
REACT_899S Phase
REACT_2148Switching of origins to a post-replicative state
REACT_2014Synthesis of DNA
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