MGP Database

MGP002176

Ontology/Pathway Information

Entrez Gene ID	5009
Gene Name	ornithine carbamoyltransferase
Gene Symbol	OTC
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005743	IEA:Ensembl	C	mitochondrial inner membrane
GO:0005759	NAS:UniProtKB	C	mitochondrial matrix
GO:0005739	IDA:BHF-UCL	C	mitochondrion
GO:0016597	IEA:InterPro	F	amino acid binding
GO:0004585	IDA:BHF-UCL	F	ornithine carbamoyltransferase activity
GO:0042301	IEA:Ensembl	F	phosphate ion binding
GO:0005543	IEA:Ensembl	F	phospholipid binding
GO:0097272	IMP:BHF-UCL	P	ammonia homeostasis
GO:0042450	IBA:GO_Central	P	arginine biosynthetic process via ornithine
GO:0034641	TAS:Reactome	P	cellular nitrogen compound metabolic process
GO:0019240	IDA:BHF-UCL	P	citrulline biosynthetic process
GO:0001889	IEA:Ensembl	P	liver development
GO:0007494	IEA:Ensembl	P	midgut development
GO:0006593	IDA:BHF-UCL	P	ornithine catabolic process
GO:0070207	IEA:Ensembl	P	protein homotrimerization
GO:0070781	IEA:Ensembl	P	response to biotin
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032868	IEA:Ensembl	P	response to insulin
GO:0010043	IEA:Ensembl	P	response to zinc ion
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0000050	IDA:BHF-UCL	P	urea cycle

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_111217	Metabolism
REACT_13	Metabolism of amino acids and derivatives
REACT_847	Urea cycle

SMP Pathway Links

SMP ID	Description
SMP00020	Arginine and Proline Metabolism
SMP00362	Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
SMP00357	Argininemia
SMP00003	Argininosuccinic Aciduria
SMP00002	Carbamoyl Phosphate Synthetase Deficiency
SMP00001	Citrullinemia Type I
SMP00504	Creatine deficiency, guanidinoacetate methyltransferase deficiency
SMP00188	Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
SMP00506	Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]
SMP00505	Hyperornithinemia with gyrate atrophy (HOGA)
SMP00361	Hyperprolinemia Type I
SMP00360	Hyperprolinemia Type II
SMP00507	L-arginine:glycine amidinotransferase deficiency
SMP00363	Ornithine Aminotransferase Deficiency (OAT Deficiency)
SMP00205	Ornithine Transcarbamylase Deficiency (OTC Deficiency)
SMP00207	Prolidase Deficiency (PD)
SMP00208	Prolinemia Type II
SMP00059	Urea Cycle