MGP Database

MGP002181

Ontology/Pathway Information

Entrez Gene ID	5021
Gene Name	oxytocin receptor
Gene Symbol	OXTR
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0016324	IEA:Ensembl	C	apical plasma membrane
GO:0005913	IEA:Ensembl	C	cell-cell adherens junction
GO:0005887	TAS:ProtInc	C	integral component of plasma membrane
GO:0005902	IEA:Ensembl	C	microvillus
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0004990	TAS:ProtInc	F	oxytocin receptor activity
GO:0042277	IBA:GO_Central	F	peptide binding
GO:0017046	IEA:Ensembl	F	peptide hormone binding
GO:0005000	IBA:GO_Central	F	vasopressin receptor activity
GO:0007166	TAS:ProtInc	P	cell surface receptor signaling pathway
GO:0032870	IBA:GO_Central	P	cellular response to hormone stimulus
GO:0048565	IEA:Ensembl	P	digestive tract development
GO:0042755	IEA:Ensembl	P	eating behavior
GO:0070371	IEA:Ensembl	P	ERK1 and ERK2 cascade
GO:0007565	TAS:ProtInc	P	female pregnancy
GO:0007186	IBA:GO_Central	P	G-protein coupled receptor signaling pathway
GO:0007507	IEA:Ensembl	P	heart development
GO:0007595	TAS:ProtInc	P	lactation
GO:0042711	IBA:GO_Central	P	maternal behavior
GO:0060137	IEA:Ensembl	P	maternal process involved in parturition
GO:0007613	IEA:Ensembl	P	memory
GO:0006936	TAS:ProtInc	P	muscle contraction
GO:0060455	IEA:Ensembl	P	negative regulation of gastric acid secretion
GO:0045777	IEA:Ensembl	P	positive regulation of blood pressure
GO:0007204	IEA:Ensembl	P	positive regulation of cytosolic calcium ion concentration
GO:0010701	IEA:Ensembl	P	positive regulation of norepinephrine secretion
GO:0060406	IEA:Ensembl	P	positive regulation of penile erection
GO:0051965	IEA:Ensembl	P	positive regulation of synapse assembly
GO:0032230	IEA:Ensembl	P	positive regulation of synaptic transmission, GABAergic
GO:0051968	IEA:Ensembl	P	positive regulation of synaptic transmission, glutamatergic
GO:0070474	IEA:Ensembl	P	positive regulation of uterine smooth muscle contraction
GO:0045907	IBA:GO_Central	P	positive regulation of vasoconstriction
GO:0001992	IBA:GO_Central	P	regulation of systemic arterial blood pressure by vasopressin
GO:0001975	IEA:Ensembl	P	response to amphetamine
GO:0034059	IEA:Ensembl	P	response to anoxia
GO:0042220	IEA:Ensembl	P	response to cocaine
GO:0034097	IEA:Ensembl	P	response to cytokine
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:1901652	IBA:GO_Central	P	response to peptide
GO:0043434	IEA:Ensembl	P	response to peptide hormone
GO:0032570	IEA:Ensembl	P	response to progesterone
GO:0030431	IEA:Ensembl	P	sleep
GO:0035176	IBA:GO_Central	P	social behavior
GO:0042713	IEA:Ensembl	P	sperm ejaculation
GO:0001967	IEA:Ensembl	P	suckling behavior
GO:0021537	IEA:Ensembl	P	telencephalon development

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_267874	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
REACT_116125	Disease
REACT_18283	G alpha (q) signalling events
REACT_120966	Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19184	GPCR downstream signaling
REACT_21340	GPCR ligand binding
REACT_267615	Metabolic disorders of biological oxidation enzymes
REACT_14819	Peptide ligand-binding receptors
REACT_14797	Signaling by GPCR
REACT_111102	Signal Transduction
REACT_17041	Vasopressin-like receptors