MGP Database

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MGP002197

Ontology/Pathway Information

Entrez Gene ID5058
Gene Namep21 protein (Cdc42/Rac)-activated kinase 1
Gene Symbol PAK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 ISS:UniProtKBCaxon
GO:0005911 IDA:UniProtKBCcell-cell junction
GO:0005737 IDA:HGNCCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0030425 ISS:UniProtKBCdendrite
GO:0005925 IEA:UniProtKB-SubCellCfocal adhesion
GO:0005794 IDA:HPACGolgi apparatus
GO:0030426 IEA:EnsemblCgrowth cone
GO:0014704 ISS:UniProtKBCintercalated disc
GO:0031965 ISS:UniProtKBCnuclear membrane
GO:0005886 IDA:HGNCCplasma membrane
GO:0043234 IDA:UniProtKBCprotein complex
GO:0001726 IDA:UniProtKBCruffle
GO:0032587 IEA:UniProtKB-SubCellCruffle membrane
GO:0030018 ISS:UniProtKBCZ disc
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005518 IPI:UniProtKBFcollagen binding
GO:0004672 IDA:UniProtKBFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0004702 IBA:GO_CentralFreceptor signaling protein serine/threonine kinase activity
GO:0031532 IDA:UniProtKBPactin cytoskeleton reorganization
GO:0006915 IEA:UniProtKB-KWPapoptotic process
GO:0007411 TAS:ReactomePaxon guidance
GO:0048754 IMP:UniProtKBPbranching morphogenesis of an epithelial tube
GO:0032869 IEA:EnsemblPcellular response to insulin stimulus
GO:0016358 IEA:EnsemblPdendrite development
GO:0006887 IEA:UniProtKB-KWPexocytosis
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 TAS:ReactomePinnate immune response
GO:0060244 IMP:UniProtKBPnegative regulation of cell proliferation involved in contact inhibition
GO:0007528 IEA:EnsemblPneuromuscular junction development
GO:0048812 ISS:UniProtKBPneuron projection morphogenesis
GO:0033148 IDA:UniProtKBPpositive regulation of intracellular estrogen receptor signaling pathway
GO:0043507 IMP:UniProtKBPpositive regulation of JUN kinase activity
GO:0033138 IDA:UniProtKBPpositive regulation of peptidyl-serine phosphorylation
GO:0001934 IMP:UniProtKBPpositive regulation of protein phosphorylation
GO:0051496 IMP:UniProtKBPpositive regulation of stress fiber assembly
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0043113 IEA:EnsemblPreceptor clustering
GO:0001666 IEA:EnsemblPresponse to hypoxia
GO:0023014 IBA:GOCPsignal transduction by phosphorylation
GO:0031295 TAS:ReactomePT cell costimulation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0042060 IMP:UniProtKBPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_19226Activation of Rac
REACT_75774Adaptive Immune System
REACT_18266Axon guidance
REACT_19183CD28 co-stimulation
REACT_19238CD28 dependent Vav1 pathway
REACT_111155Cell-Cell communication
REACT_19344Costimulation by the CD28 family
REACT_111045Developmental Biology
REACT_25299DSCAM interactions
REACT_263952EPHB-mediated forward signaling
REACT_264068EPH-Ephrin signaling
REACT_264047Ephrin signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_12623Generation of second messenger molecules
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_22205L1CAM interactions
REACT_160086Regulation of actin dynamics for phagocytic cup formation
REACT_19236Sema3A PAK dependent Axon repulsion
REACT_19271Semaphorin interactions
REACT_19351Signaling by Robo receptor
REACT_12529Signaling by VEGF
REACT_111102Signal Transduction
REACT_22272Signal transduction by L1
REACT_12526TCR signaling
REACT_264464VEGFA-VEGFR2 Pathway
REACT_263991VEGFR2 mediated vascular permeability
SMP Pathway Links
SMP IDDescription
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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