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MGP002218

UniProt Annotations

Entry Information
Gene Nameprocollagen C-endopeptidase enhancer
Protein EntryPCOC1_HUMAN
UniProt IDQ15113
SpeciesHuman
Comments
Comment typeDescription
FunctionBinds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
FunctionC-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
InteractionP05067:APP; NbExp=3; IntAct=EBI-8869614, EBI-821758; P39060:COL18A1; NbExp=4; IntAct=EBI-8869614, EBI-2566375; P07996:THBS1; NbExp=3; IntAct=EBI-8869614, EBI-2530274;
PtmC-terminally processed at multiple positions.
SimilarityContains 1 NTR domain. {ECO:0000255|PROSITE- ProRule:PRU00295}.
SimilarityContains 2 CUB domains. {ECO:0000255|PROSITE- ProRule:PRU00059}.
Subcellular LocationSecreted.
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