MGP Database

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MGP002219

Ontology/Pathway Information

Entrez Gene ID5122
Gene Nameproprotein convertase subtilisin/kexin type 1
Gene Symbol PCSK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0005794 IBA:GO_CentralCGolgi apparatus
GO:0034774 TAS:ReactomeCsecretory granule lumen
GO:0030133 IEA:UniProtKB-SubCellCtransport vesicle
GO:0004252 ISS:BHF-UCLFserine-type endopeptidase activity
GO:0007267 TAS:ProtIncPcell-cell signaling
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0008152 TAS:ProtIncPmetabolic process
GO:0043043 ISS:BHF-UCLPpeptide biosynthetic process
GO:0016486 TAS:ReactomePpeptide hormone processing
GO:0006508 TAS:ProtIncPproteolysis
GO:0050796 TAS:ReactomePregulation of insulin secretion
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_23974Incretin synthesis, secretion, and inactivation
REACT_15550Insulin processing
REACT_17015Metabolism of proteins
REACT_15452Peptide hormone biosynthesis
REACT_160078Peptide hormone metabolism
REACT_19189Synthesis, secretion, and deacylation of Ghrelin
REACT_24019Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_23824Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
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