MGP Database

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MGP002226

Ontology/Pathway Information

Entrez Gene ID5156
Gene Nameplatelet-derived growth factor receptor, alpha polypeptide
Gene Symbol PDGFRA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0009897 IEA:EnsemblCexternal side of plasma membrane
GO:0005887 IDA:BHF-UCLCintegral component of plasma membrane
GO:0031226 IDA:UniProtKBCintrinsic component of plasma membrane
GO:0016020 IDA:UniProtKBCmembrane
GO:0005902 IEA:EnsemblCmicrovillus
GO:0005634 ISS:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0005018 IDA:UniProtKBFplatelet-derived growth factor alpha-receptor activity
GO:0048407 IDA:UniProtKBFplatelet-derived growth factor binding
GO:0005161 IPI:BHF-UCLFplatelet-derived growth factor receptor binding
GO:0042803 IDA:BHF-UCLFprotein homodimerization activity
GO:0004714 IDA:UniProtKBFtransmembrane receptor protein tyrosine kinase activity
GO:0005021 IDA:BHF-UCLFvascular endothelial growth factor-activated receptor activity
GO:0038085 IPI:BHF-UCLFvascular endothelial growth factor binding
GO:0030325 IEA:EnsemblPadrenal gland development
GO:0055003 ISS:UniProtKBPcardiac myofibril assembly
GO:0001775 TAS:BHF-UCLPcell activation
GO:0060326 IMP:UniProtKBPcell chemotaxis
GO:0071230 IEA:EnsemblPcellular response to amino acid stimulus
GO:0048701 ISS:UniProtKBPembryonic cranial skeleton morphogenesis
GO:0048557 ISS:UniProtKBPembryonic digestive tract morphogenesis
GO:0048704 ISS:UniProtKBPembryonic skeletal system morphogenesis
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0008210 IEA:EnsemblPestrogen metabolic process
GO:0030198 IEA:EnsemblPextracellular matrix organization
GO:0060325 IEA:EnsemblPface morphogenesis
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0002244 IEA:EnsemblPhematopoietic progenitor cell differentiation
GO:0045087 TAS:ReactomePinnate immune response
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0033327 IEA:EnsemblPLeydig cell differentiation
GO:0030324 IEA:EnsemblPlung development
GO:0001553 ISS:UniProtKBPluteinization
GO:0030539 IEA:EnsemblPmale genitalia development
GO:0072277 ISS:UniProtKBPmetanephric glomerular capillary formation
GO:0010544 IDA:UniProtKBPnegative regulation of platelet activation
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0042475 IEA:EnsemblPodontogenesis of dentin-containing tooth
GO:0060021 IEA:EnsemblPpalate development
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0048015 IMP:UniProtKBPphosphatidylinositol-mediated signaling
GO:0070527 IMP:UniProtKBPplatelet aggregation
GO:0035790 IMP:UniProtKBPplatelet-derived growth factor receptor-alpha signaling pathway
GO:0048008 IDA:BHF-UCLPplatelet-derived growth factor receptor signaling pathway
GO:0030335 IMP:UniProtKBPpositive regulation of cell migration
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0038091 IDA:BHF-UCLPpositive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0007204 IMP:UniProtKBPpositive regulation of cytosolic calcium ion concentration
GO:0045740 IDA:BHF-UCLPpositive regulation of DNA replication
GO:0070374 IMP:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0048146 IDA:BHF-UCLPpositive regulation of fibroblast proliferation
GO:0043552 IMP:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0014068 TAS:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0010863 IMP:UniProtKBPpositive regulation of phospholipase C activity
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:2000249 TAS:UniProtKBPregulation of actin cytoskeleton reorganization
GO:0050920 IMP:UniProtKBPregulation of chemotaxis
GO:2000739 IMP:UniProtKBPregulation of mesenchymal stem cell differentiation
GO:0061298 ISS:UniProtKBPretina vasculature development in camera-type eye
GO:0023019 IEA:EnsemblPsignal transduction involved in regulation of gene expression
GO:0016032 IEA:UniProtKB-KWPviral process
GO:0042060 ISS:UniProtKBPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
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