MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002227

Ontology/Pathway Information

Entrez Gene ID5159
Gene Nameplatelet-derived growth factor receptor, beta polypeptide
Gene Symbol PDGFRB
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016324 ISS:UniProtKBCapical plasma membrane
GO:0009986 IEA:EnsemblCcell surface
GO:0005737 ISS:UniProtKBCcytoplasm
GO:0016023 IEA:UniProtKB-SubCellCcytoplasmic membrane-bounded vesicle
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005925 IDA:UniProtKBCfocal adhesion
GO:0016021 IEA:UniProtKB-KWCintegral component of membrane
GO:0031226 IDA:UniProtKBCintrinsic component of plasma membrane
GO:0043202 IEA:UniProtKB-SubCellClysosomal lumen
GO:0016020 IDA:UniProtKBCmembrane
GO:0005634 ISS:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004992 TAS:ProtIncFplatelet activating factor receptor activity
GO:0005017 TAS:ProtIncFplatelet-derived growth factor-activated receptor activity
GO:0005019 IDA:UniProtKBFplatelet-derived growth factor beta-receptor activity
GO:0048407 IDA:UniProtKBFplatelet-derived growth factor binding
GO:0005161 IPI:BHF-UCLFplatelet-derived growth factor receptor binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0004713 IDA:UniProtKBFprotein tyrosine kinase activity
GO:0005102 IPI:UniProtKBFreceptor binding
GO:0038085 IPI:BHF-UCLFvascular endothelial growth factor binding
GO:0030325 IEA:EnsemblPadrenal gland development
GO:0035909 ISS:BHF-UCLPaorta morphogenesis
GO:0055003 ISS:UniProtKBPcardiac myofibril assembly
GO:0060326 IDA:UniProtKBPcell chemotaxis
GO:0016477 IMP:UniProtKBPcell migration
GO:0060981 ISS:UniProtKBPcell migration involved in coronary angiogenesis
GO:0035441 ISS:UniProtKBPcell migration involved in vasculogenesis
GO:0036120 TAS:GOCPcellular response to platelet-derived growth factor stimulus
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0006024 IEA:EnsemblPglycosaminoglycan biosynthetic process
GO:0007186 TAS:GOCPG-protein coupled receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0048839 IEA:EnsemblPinner ear development
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0072278 IEA:EnsemblPmetanephric comma-shaped body morphogenesis
GO:0072277 ISS:UniProtKBPmetanephric glomerular capillary formation
GO:0072262 ISS:UniProtKBPmetanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0035789 IEA:EnsemblPmetanephric mesenchymal cell migration
GO:0072075 IEA:EnsemblPmetanephric mesenchyme development
GO:0072284 IEA:EnsemblPmetanephric S-shaped body morphogenesis
GO:0043066 IEA:EnsemblPnegative regulation of apoptotic process
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0018108 IDA:UniProtKBPpeptidyl-tyrosine phosphorylation
GO:0048015 IMP:UniProtKBPphosphatidylinositol-mediated signaling
GO:0046488 IMP:UniProtKBPphosphatidylinositol metabolic process
GO:0035791 IMP:UniProtKBPplatelet-derived growth factor receptor-beta signaling pathway
GO:0048008 IDA:UniProtKBPplatelet-derived growth factor receptor signaling pathway
GO:0090280 ISS:UniProtKBPpositive regulation of calcium ion import
GO:0030335 IDA:BHF-UCLPpositive regulation of cell migration
GO:0008284 IMP:UniProtKBPpositive regulation of cell proliferation
GO:0038091 IDA:BHF-UCLPpositive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0050921 ISS:UniProtKBPpositive regulation of chemotaxis
GO:0032967 IEA:EnsemblPpositive regulation of collagen biosynthetic process
GO:2000573 ISS:UniProtKBPpositive regulation of DNA biosynthetic process
GO:0070374 IMP:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0043406 ISS:UniProtKBPpositive regulation of MAP kinase activity
GO:0035793 ISS:UniProtKBPpositive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0045840 ISS:UniProtKBPpositive regulation of mitosis
GO:0043552 IDA:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase activity
GO:0014068 ISS:UniProtKBPpositive regulation of phosphatidylinositol 3-kinase signaling
GO:0010863 IDA:UniProtKBPpositive regulation of phospholipase C activity
GO:0032516 IDA:UniProtKBPpositive regulation of phosphoprotein phosphatase activity
GO:2000379 ISS:UniProtKBPpositive regulation of reactive oxygen species metabolic process
GO:0014911 IMP:UniProtKBPpositive regulation of smooth muscle cell migration
GO:0048661 IMP:UniProtKBPpositive regulation of smooth muscle cell proliferation
GO:0046777 IDA:UniProtKBPprotein autophosphorylation
GO:0032956 ISS:BHF-UCLPregulation of actin cytoskeleton organization
GO:0050730 IEA:EnsemblPregulation of peptidyl-tyrosine phosphorylation
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0034405 IEA:EnsemblPresponse to fluid shear stress
GO:0042542 IEA:EnsemblPresponse to hydrogen peroxide
GO:0055093 IEA:EnsemblPresponse to hyperoxia
GO:0032526 IEA:EnsemblPresponse to retinoic acid
GO:0009636 IEA:EnsemblPresponse to toxic substance
GO:0061298 ISS:UniProtKBPretina vasculature development in camera-type eye
GO:0007165 IDA:UniProtKBPsignal transduction
GO:0048705 IEA:EnsemblPskeletal system morphogenesis
GO:0071670 ISS:BHF-UCLPsmooth muscle cell chemotaxis
GO:0048745 IEA:EnsemblPsmooth muscle tissue development
GO:0001894 IEA:EnsemblPtissue homeostasis
GO:0042060 IEA:EnsemblPwound healing
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
  logo