MGP Database

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MGP002228

Ontology/Pathway Information

Entrez Gene ID5160
Gene Namepyruvate dehydrogenase (lipoamide) alpha 1
Gene Symbol PDHA1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005759 TAS:ReactomeCmitochondrial matrix
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0005634 IDA:UniProtKBCnucleus
GO:0045254 IDA:UniProtKBCpyruvate dehydrogenase complex
GO:0004739 IEA:UniProtKB-ECFpyruvate dehydrogenase (acetyl-transferring) activity
GO:0004738 IDA:UniProtKBFpyruvate dehydrogenase activity
GO:0006086 IDA:UniProtKBPacetyl-CoA biosynthetic process from pyruvate
GO:0044237 TAS:ReactomePcellular metabolic process
GO:0006006 IEA:UniProtKB-KWPglucose metabolic process
GO:0006096 IEA:InterProPglycolytic process
GO:0006090 TAS:ReactomePpyruvate metabolic process
GO:0010510 TAS:ReactomePregulation of acetyl-CoA biosynthetic process from pyruvate
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006099 IDA:UniProtKBPtricarboxylic acid cycle
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111217Metabolism
REACT_2071Pyruvate metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_12528Regulation of pyruvate dehydrogenase (PDH) complex
REACT_267785Signaling by Retinoic Acid
REACT_111102Signal Transduction
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
SMP Pathway Links
SMP IDDescription
SMP005492-ketoglutarate dehydrogenase complex deficiency
SMP00057Citric Acid Cycle
SMP00546Congenital lactic acidosis
SMP00547Fumarase deficiency
SMP00196Leigh Syndrome
SMP00548Mitochondrial complex II deficiency
SMP00558Primary hyperoxaluria II, PH2
SMP00334Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
SMP00212Pyruvate Dehydrogenase Complex Deficiency
SMP00551Pyruvate dehydrogenase deficiency (E2)
SMP00550Pyruvate dehydrogenase deficiency (E3)
SMP00559Pyruvate kinase deficiency
SMP00060Pyruvate Metabolism
SMP00466Transfer of Acetyl Groups into Mitochondria
SMP00654Warburg Effect
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