MGP Database

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MGP002234

Ontology/Pathway Information

Entrez Gene ID5167
Gene Nameectonucleotide pyrophosphatase/phosphodiesterase 1
Gene Symbol ENPP1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0016323 NAS:BHF-UCLCbasolateral plasma membrane
GO:0009986 IDA:BHF-UCLCcell surface
GO:0005615 IDA:BHF-UCLCextracellular space
GO:0016021 ISS:UniProtKBCintegral component of membrane
GO:0005887 ISS:UniProtKBCintegral component of plasma membrane
GO:0005765 IDA:UniProtKBClysosomal membrane
GO:0005886 IDA:BHF-UCLCplasma membrane
GO:0050656 IC:BHF-UCLF3'-phosphoadenosine 5'-phosphosulfate binding
GO:0005524 IDA:BHF-UCLFATP binding
GO:0005509 ISS:UniProtKBFcalcium ion binding
GO:0005158 IDA:BHF-UCLFinsulin receptor binding
GO:0035529 IEA:UniProtKB-ECFNADH pyrophosphatase activity
GO:0003676 IEA:InterProFnucleic acid binding
GO:0047429 IDA:BHF-UCLFnucleoside-triphosphate diphosphatase activity
GO:0004551 IDA:BHF-UCLFnucleotide diphosphatase activity
GO:0004528 ISS:UniProtKBFphosphodiesterase I activity
GO:0030247 IEA:InterProFpolysaccharide binding
GO:0042803 IDA:BHF-UCLFprotein homodimerization activity
GO:0005044 IEA:InterProFscavenger receptor activity
GO:0008270 ISS:UniProtKBFzinc ion binding
GO:0050427 IDA:BHF-UCLP3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0006200 ISS:UniProtKBPATP catabolic process
GO:0031214 IEA:UniProtKB-KWPbiomineral tissue development
GO:0046849 IEA:EnsemblPbone remodeling
GO:0030643 IDA:BHF-UCLPcellular phosphate ion homeostasis
GO:0032869 IDA:BHF-UCLPcellular response to insulin stimulus
GO:0006091 IDA:BHF-UCLPgeneration of precursor metabolites and energy
GO:0006955 IEA:InterProPimmune response
GO:0030505 IDA:BHF-UCLPinorganic diphosphate transport
GO:0030308 IDA:BHF-UCLPnegative regulation of cell growth
GO:0045599 IDA:BHF-UCLPnegative regulation of fat cell differentiation
GO:0046325 IDA:BHF-UCLPnegative regulation of glucose import
GO:0045719 IDA:BHF-UCLPnegative regulation of glycogen biosynthetic process
GO:0046627 IDA:BHF-UCLPnegative regulation of insulin receptor signaling pathway
GO:0030279 IEA:EnsemblPnegative regulation of ossification
GO:0031953 IDA:BHF-UCLPnegative regulation of protein autophosphorylation
GO:0090305 ISS:GOCPnucleic acid phosphodiester bond hydrolysis
GO:0009143 IDA:BHF-UCLPnucleoside triphosphate catabolic process
GO:0006796 IDA:BHF-UCLPphosphate-containing compound metabolic process
GO:0030500 IC:BHF-UCLPregulation of bone mineralization
GO:0006771 TAS:ReactomePriboflavin metabolic process
GO:0030730 IDA:BHF-UCLPsequestering of triglyceride
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0006766 TAS:ReactomePvitamin metabolic process
GO:0006767 TAS:ReactomePwater-soluble vitamin metabolic process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_169280Defective AMN causes hereditary megaloblastic anemia 1
REACT_169403Defective BTD causes biotidinase deficiency
REACT_169178Defective CD320 causes methylmalonic aciduria
REACT_169132Defective CUBN causes hereditary megaloblastic anemia 1
REACT_169415Defective GIF causes intrinsic factor deficiency
REACT_169312Defective HLCS causes multiple carboxylase deficiency
REACT_169363Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
REACT_169316Defective MMAA causes methylmalonic aciduria type cblA
REACT_169318Defective MMAB causes methylmalonic aciduria type cblB
REACT_169169Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
REACT_169256Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
REACT_169149Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
REACT_169439Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
REACT_169313Defective MUT causes methylmalonic aciduria mut type
REACT_169120Defective TCN2 causes hereditary megaloblastic anemia
REACT_169238Defects in biotin (Btn) metabolism
REACT_169429Defects in cobalamin (B12) metabolism
REACT_169385Defects in vitamin and cofactor metabolism
REACT_116125Disease
REACT_111217Metabolism
REACT_11193Metabolism of vitamins and cofactors
REACT_11238Metabolism of water-soluble vitamins and cofactors
REACT_11070Vitamin B2 (riboflavin) metabolism
SMP Pathway Links
SMP IDDescription
SMP00048Nicotinate and Nicotinamide Metabolism
SMP00027Pantothenate and CoA Biosynthesis
SMP00070Riboflavin Metabolism
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