MGP Database

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MGP002235

Ontology/Pathway Information

Entrez Gene ID5170
Gene Name3-phosphoinositide dependent protein kinase 1
Gene Symbol PDPK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0042995 IDA:BHF-UCLCcell projection
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0016023 IEA:EnsemblCcytoplasmic membrane-bounded vesicle
GO:0005829 TAS:ReactomeCcytosol
GO:0005925 IEA:UniProtKB-SubCellCfocal adhesion
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0004676 IDA:BHF-UCLF3-phosphoinositide-dependent protein kinase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0016301 EXP:ReactomeFkinase activity
GO:0016004 IMP:BHF-UCLFphospholipase activator activity
GO:0043274 IPI:BHF-UCLFphospholipase binding
GO:0004674 IDA:BHF-UCLFprotein serine/threonine kinase activity
GO:0030036 TAS:ProtIncPactin cytoskeleton organization
GO:0032148 IDA:BHF-UCLPactivation of protein kinase B activity
GO:0007596 TAS:ReactomePblood coagulation
GO:0019722 IMP:BHF-UCLPcalcium-mediated signaling
GO:0016477 IMP:BHF-UCLPcell migration
GO:0071364 IMP:BHF-UCLPcellular response to epidermal growth factor stimulus
GO:0032869 IMP:BHF-UCLPcellular response to insulin stimulus
GO:0007173 IMP:BHF-UCLPepidermal growth factor receptor signaling pathway
GO:0097191 IMP:UniProtKBPextrinsic apoptotic signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0048041 IEA:EnsemblPfocal adhesion assembly
GO:0006972 IEA:EnsemblPhyperosmotic response
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0035556 IDA:MGIPintracellular signal transduction
GO:0010667 IEA:EnsemblPnegative regulation of cardiac muscle cell apoptotic process
GO:0006469 IDA:BHF-UCLPnegative regulation of protein kinase activity
GO:0034122 IEA:EnsemblPnegative regulation of toll-like receptor signaling pathway
GO:0030512 IDA:UniProtKBPnegative regulation of transforming growth factor beta receptor signaling pathway
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0018107 IDA:BHF-UCLPpeptidyl-threonine phosphorylation
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0030168 TAS:ReactomePplatelet activation
GO:0090004 IMP:BHF-UCLPpositive regulation of establishment of protein localization to plasma membrane
GO:0010518 IMP:BHF-UCLPpositive regulation of phospholipase activity
GO:0051281 IDA:BHF-UCLPpositive regulation of release of sequestered calcium ion into cytosol
GO:0046777 TAS:UniProtKBPprotein autophosphorylation
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0010594 IEA:EnsemblPregulation of endothelial cell migration
GO:0043122 IMP:UniProtKBPregulation of I-kappaB kinase/NF-kappaB signaling
GO:0043304 IEA:EnsemblPregulation of mast cell degranulation
GO:0006355 IEA:UniProtKB-KWPregulation of transcription, DNA-templated
GO:0007268 TAS:ReactomePsynaptic transmission
GO:0031295 TAS:ReactomePT cell costimulation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
GO:0003323 IEA:EnsemblPtype B pancreatic cell development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_790Activation of PKB
REACT_75774Adaptive Immune System
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_19344Costimulation by the CD28 family
REACT_20568CREB phosphorylation through the activation of Ras
REACT_19405CTLA4 inhibitory signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163994FCERI mediated NF-kB activation
REACT_12578GAB1 signalosome
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_15523Integrin alphaIIb beta3 signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_20593Post NMDA receptor activation events
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_20510RSK activation
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_12526TCR signaling
REACT_13477Transmission across Chemical Synapses
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
REACT_263991VEGFR2 mediated vascular permeability
SMP Pathway Links
SMP IDDescription
SMP00391Insulin Signalling
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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