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MGP002238

UniProt Annotations

Entry Information
Gene Nameproenkephalin
Protein EntryPENK_HUMAN
UniProt IDP01210
SpeciesHuman
Comments
Comment typeDescription
FunctionMet- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
PtmThe N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
SimilarityBelongs to the opioid neuropeptide precursor family. {ECO:0000305}.
Subcellular LocationSecreted.
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