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MGP002241

Record overview

MGPD IDMGP002241
Gene ID5195
SpeciesHomo sapiens (Human)
Gene Nameperoxisomal biogenesis factor 14
Gene Symbol PEX14
SynonymsNAPP2; PBD13A; Pex14p; dJ734G22.2;
Alternate namesperoxisomal membrane protein PEX14; NF-E2 associated polypeptide 2; PTS1 receptor docking protein; PTS1 receptor-docking protein; peroxin-14; peroxisomal membrane anchor protein PEX14; peroxisomal membrane anchor protein Pex14p;
Chromosome1
Map Location1p36.22
SummaryThis gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PEX14

Proteins

peroxisomal membrane protein PEX14
Refseq ID:NP_004556
Protein GI:4758896
UniProt ID:O75381
mRNA ID:NM_004565
Length:377
RefSeq Status:
MASSEQAEQPSQPSSTPGSENVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYS
PAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTST
NWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGE
GVVDVKGQVRMEVQGEEEKREDKEDEEDEEDDDVSHVDEEDCLGVQREDRRGGDGQINEQVEKLRRPEGASNESERD
 
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