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MGP002244

UniProt Annotations

Entry Information
Gene Namephosphoribosylformylglycinamidine synthase
Protein EntryPUR4_HUMAN
UniProt IDO15067
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
FunctionPhosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). {ECO:0000250}.
InteractionP11171:EPB41; NbExp=1; IntAct=EBI-1052653, EBI-1050906; P30480:HLA-B; NbExp=1; IntAct=EBI-1052653, EBI-1054175; P23508:MCC; NbExp=1; IntAct=EBI-1052653, EBI-307531; P19532:TFE3; NbExp=1; IntAct=EBI-1052653, EBI-1048957; Q9UBN6:TNFRSF10D; NbExp=1; IntAct=EBI-1052653, EBI-1044859; Q9Y4K3:TRAF6; NbExp=1; IntAct=EBI-1052653, EBI-359276; P40337:VHL; NbExp=1; IntAct=EBI-1052653, EBI-301246;
PathwayPurine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5- phospho-D-ribosyl)glycinamide: step 1/2.
Sequence CautionSequence=BAA20816.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
SimilarityContains 1 glutamine amidotransferase type-1 domain. {ECO:0000305}.
SimilarityIn the N-terminal section; belongs to the FGAMS family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
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