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MGP002257

UniProt Annotations

Entry Information
Gene Namephosphofructokinase, platelet
Protein EntryPFKAP_HUMAN
UniProt IDQ01813
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q01813-1; Sequence=Displayed; Name=2; IsoId=Q01813-2; Sequence=VSP_046416; Note=No experimental confirmation available.;
Catalytic ActivityATP + D-fructose 6-phosphate = ADP + D- fructose 1,6-bisphosphate. {ECO:0000255|HAMAP-Rule:MF_03184}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme RegulationAllosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. {ECO:0000255|HAMAP-Rule:MF_03184}.
FunctionCatalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
MiscellaneousIn human PFK exists as a system of 3 types of subunits, PFKM (muscle), PFKL (liver) and PFKP (platelet) isoenzymes.
PathwayCarbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO:0000255|HAMAP-Rule:MF_03184}.
PtmGlcNAcylation decreases enzyme activity. {ECO:0000250}.
SimilarityBelongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. {ECO:0000255|HAMAP-Rule:MF_03184}.
Subcellular LocationCytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
SubunitHomo- and heterotetramers. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts.
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