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MGP002260

UniProt Annotations

Entry Information
Gene Namephosphoglycerate mutase 1 (brain)
Protein EntryPGAM1_HUMAN
UniProt IDP18669
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity2,3-bisphospho-D-glycerate + H(2)O = 3- phospho-D-glycerate + phosphate.
Catalytic Activity2-phospho-D-glycerate = 3-phospho-D-glycerate.
Catalytic Activity3-phospho-D-glyceroyl phosphate = 2,3- bisphospho-D-glycerate.
FunctionInterconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.
InteractionP12004:PCNA; NbExp=2; IntAct=EBI-717905, EBI-358311;
PtmAcetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme. {ECO:0000269|PubMed:22157007}.
SimilarityBelongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. {ECO:0000305}.
SubunitHomodimer. {ECO:0000269|PubMed:15883004}.
Tissue SpecificityIn mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues.
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