MGP Database

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MGP002262

UniProt Annotations

Entry Information
Gene Namephosphogluconate dehydrogenase
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P52209-1; Sequence=Displayed; Name=2; IsoId=P52209-2; Sequence=VSP_055767; Note=No experimental confirmation available.;
Catalytic Activity6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.
FunctionCatalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}.
PathwayCarbohydrate degradation; pentose phosphate pathway; D- ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
SimilarityBelongs to the 6-phosphogluconate dehydrogenase family. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000250}.
SubunitHomodimer. {ECO:0000269|Ref.8}.
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