MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP002287

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Protein EntryP3C2B_HUMAN
UniProt IDO00750
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
CautionIt is uncertain whether Met-1 or Met-26 is the initiator. {ECO:0000305}.
CofactorName=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:10805725}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:10805725}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:10805725};
Enzyme RegulationActivated by GRB2. {ECO:0000269|PubMed:11533253}.
FunctionPhosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. {ECO:0000269|PubMed:10805725}.
InteractionP00533:EGFR; NbExp=9; IntAct=EBI-641107, EBI-297353; P04626:ERBB2; NbExp=2; IntAct=EBI-641107, EBI-641062; P62993:GRB2; NbExp=2; IntAct=EBI-641107, EBI-401755; P16333:NCK1; NbExp=3; IntAct=EBI-641107, EBI-389883; P14373:TRIM27; NbExp=5; IntAct=EBI-641107, EBI-719493;
Sequence CautionSequence=CAA74194.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the PI3/PI4-kinase family. {ECO:0000255|PROSITE-ProRule:PRU00879, ECO:0000255|PROSITE- ProRule:PRU00880}.
SimilarityContains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
SimilarityContains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE- ProRule:PRU00880}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 1 PI3K-RBD domain. {ECO:0000255|PROSITE- ProRule:PRU00879}.
SimilarityContains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
SimilarityContains 1 PX (phox homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00147}.
Subcellular LocationMicrosome {ECO:0000269|PubMed:14563213}. Cell membrane {ECO:0000269|PubMed:14563213}. Cytoplasm, cytosol {ECO:0000269|PubMed:14563213}. Nucleus {ECO:0000269|PubMed:14563213}. Endoplasmic reticulum {ECO:0000269|PubMed:14563213}. Note=Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis.
SubunitPart of a complex with ERBB2 and EGFR. Part of a complex with phosphorylated EGFR and GRB2. Interacts with phosphorylated EGFR and PDGFR, maybe indirectly. Interacts with GRB2 and SHC1. {ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11533253}.
Tissue SpecificityExpressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney. {ECO:0000269|PubMed:14563213, ECO:0000269|PubMed:9144573}.
  logo