MGP Database

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MGP002288

UniProt Annotations

Entry Information
Gene Namephosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Protein EntryP3C2G_HUMAN
UniProt IDO75747
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
FunctionGenerates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity). {ECO:0000250}.
Sequence CautionSequence=CAA03853.1; Type=Erroneous termination; Positions=1446; Note=Translated as stop.; Evidence={ECO:0000305};
SimilarityBelongs to the PI3/PI4-kinase family. {ECO:0000255|PROSITE-ProRule:PRU00879, ECO:0000255|PROSITE- ProRule:PRU00880}.
SimilarityContains 1 C2 domain. {ECO:0000305}.
SimilarityContains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE- ProRule:PRU00880}.
SimilarityContains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
SimilarityContains 1 PI3K-RBD domain. {ECO:0000255|PROSITE- ProRule:PRU00879}.
SimilarityContains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
SimilarityContains 1 PX (phox homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00147}.
Subcellular LocationMembrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue SpecificityHighly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas. {ECO:0000269|PubMed:9878262}.
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