MGP Database

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MGP002290

Ontology/Pathway Information

Entrez Gene ID5290
Gene Namephosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Gene Symbol PIK3CA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0030027 IEA:EnsemblClamellipodium
GO:0005942 ISS:BHF-UCLCphosphatidylinositol 3-kinase complex
GO:0005943 IDA:UniProtKBCphosphatidylinositol 3-kinase complex, class IA
GO:0005886 IBA:GO_CentralCplasma membrane
GO:0016303 IDA:UniProtKBF1-phosphatidylinositol-3-kinase activity
GO:0035005 IBA:GO_CentralF1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0016301 TAS:ReactomeFkinase activity
GO:0035004 TAS:UniProtKBFphosphatidylinositol 3-kinase activity
GO:0046934 TAS:ReactomeFphosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0030295 IEA:EnsemblFprotein kinase activator activity
GO:0004674 IEA:UniProtKB-KWFprotein serine/threonine kinase activity
GO:0001525 IEA:UniProtKB-KWPangiogenesis
GO:0007596 TAS:ReactomePblood coagulation
GO:0060048 TAS:UniProtKBPcardiac muscle contraction
GO:0043542 TAS:UniProtKBPendothelial cell migration
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0006006 IEA:EnsemblPglucose metabolic process
GO:0044029 IEA:EnsemblPhypomethylation of CpG island
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0038028 TAS:UniProtKBPinsulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0050900 TAS:ReactomePleukocyte migration
GO:2000811 IMP:UniProtKBPnegative regulation of anoikis
GO:2000270 IEA:EnsemblPnegative regulation of fibroblast apoptotic process
GO:0043524 IEA:EnsemblPnegative regulation of neuron apoptotic process
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0006661 TAS:ReactomePphosphatidylinositol biosynthetic process
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0046854 ISS:BHF-UCLPphosphatidylinositol phosphorylation
GO:0006644 TAS:ReactomePphospholipid metabolic process
GO:0030168 TAS:UniProtKBPplatelet activation
GO:0033138 IEA:EnsemblPpositive regulation of peptidyl-serine phosphorylation
GO:0043491 IEA:EnsemblPprotein kinase B signaling
GO:2000653 IEA:EnsemblPregulation of genetic imprinting
GO:0040014 IEA:EnsemblPregulation of multicellular organism growth
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0031295 TAS:ReactomePT cell costimulation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0001944 TAS:UniProtKBPvasculature development
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_111155Cell-Cell communication
REACT_12051Cell surface interactions at the vascular wall
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_267817Constitutive Signaling by EGFRvIII
REACT_115852Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
REACT_19344Costimulation by the CD28 family
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_12578GAB1 signalosome
REACT_18407G alpha (12/13) signalling events
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_23832Nephrin interactions
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_120870Phospholipid metabolism
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_121175PI Metabolism
REACT_75829PIP3 activates AKT signaling
REACT_798Platelet activation, signaling and aggregation
REACT_23787Regulation of signaling by CBL
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_160158Role of phospholipids in phagocytosis
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_121141Signaling by FGFR1 fusion mutants
REACT_120999Signaling by FGFR1 mutants
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_12526TCR signaling
REACT_12621Tie2 Signaling
REACT_264464VEGFA-VEGFR2 Pathway
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
SMP00011Inositol Metabolism
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
SMP00582Joubert syndrome
SMP00463Phosphatidylinositol Phosphate Metabolism
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