MGP Database

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MGP002294

Ontology/Pathway Information

Entrez Gene ID5295
Gene Namephosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Gene Symbol PIK3R1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0016020 IDA:UniProtKBCmembrane
GO:0005634 ISS:UniProtKBCnucleus
GO:0005942 ISS:BHF-UCLCphosphatidylinositol 3-kinase complex
GO:0005943 ISS:UniProtKBCphosphatidylinositol 3-kinase complex, class IA
GO:0005886 TAS:ReactomeCplasma membrane
GO:0043125 IDA:UniProtKBFErbB-3 class receptor binding
GO:0043559 IDA:UniProtKBFinsulin binding
GO:0005159 IPI:UniProtKBFinsulin-like growth factor receptor binding
GO:0005158 IPI:UniProtKBFinsulin receptor binding
GO:0043560 ISS:BHF-UCLFinsulin receptor substrate binding
GO:0005168 IPI:UniProtKBFneurotrophin TRKA receptor binding
GO:0043548 ISS:BHF-UCLFphosphatidylinositol 3-kinase binding
GO:0035014 ISS:UniProtKBFphosphatidylinositol 3-kinase regulator activity
GO:0019903 IPI:UniProtKBFprotein phosphatase binding
GO:0008134 IPI:UniProtKBFtranscription factor binding
GO:0005068 ISS:BHF-UCLFtransmembrane receptor protein tyrosine kinase adaptor activity
GO:0030183 IEA:EnsemblPB cell differentiation
GO:0007596 TAS:ReactomePblood coagulation
GO:0001678 ISS:UniProtKBPcellular glucose homeostasis
GO:0032869 ISS:UniProtKBPcellular response to insulin stimulus
GO:0034644 IEA:EnsemblPcellular response to UV
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0008625 IEA:EnsemblPextrinsic apoptotic signaling pathway via death domain receptors
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0060396 IDA:BHF-UCLPgrowth hormone receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0048009 IPI:UniProtKBPinsulin-like growth factor receptor signaling pathway
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0008630 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0050900 TAS:ReactomePleukocyte migration
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0001953 IEA:EnsemblPnegative regulation of cell-matrix adhesion
GO:0045671 IEA:EnsemblPnegative regulation of osteoclast differentiation
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0051531 IEA:EnsemblPNFAT protein import into nucleus
GO:0014065 IDA:BHF-UCLPphosphatidylinositol 3-kinase signaling
GO:0006661 TAS:ReactomePphosphatidylinositol biosynthetic process
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0046854 ISS:UniProtKBPphosphatidylinositol phosphorylation
GO:0006644 TAS:ReactomePphospholipid metabolic process
GO:0030168 TAS:ReactomePplatelet activation
GO:0030335 IEA:EnsemblPpositive regulation of cell migration
GO:1900103 IMP:UniProtKBPpositive regulation of endoplasmic reticulum unfolded protein response
GO:0090004 ISS:BHF-UCLPpositive regulation of establishment of protein localization to plasma membrane
GO:0046326 ISS:BHF-UCLPpositive regulation of glucose import
GO:0033120 IMP:UniProtKBPpositive regulation of RNA splicing
GO:0042993 IDA:UniProtKBPpositive regulation of transcription factor import into nucleus
GO:0045944 IMP:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0032760 IEA:EnsemblPpositive regulation of tumor necrosis factor production
GO:0006468 IEA:EnsemblPprotein phosphorylation
GO:0050821 IDA:UniProtKBPprotein stabilization
GO:0043551 ISS:BHF-UCLPregulation of phosphatidylinositol 3-kinase activity
GO:0034976 IDA:UniProtKBPresponse to endoplasmic reticulum stress
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0031295 TAS:ReactomePT cell costimulation
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_111155Cell-Cell communication
REACT_12051Cell surface interactions at the vascular wall
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_267817Constitutive Signaling by EGFRvIII
REACT_115852Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
REACT_19344Costimulation by the CD28 family
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12555Downstream TCR signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_12578GAB1 signalosome
REACT_18407G alpha (12/13) signalling events
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_23847GP1b-IX-V activation signalling
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_27283Interleukin-2 signaling
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_115529Interleukin-7 signaling
REACT_23891Interleukin receptor SHC signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_23832Nephrin interactions
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_120870Phospholipid metabolism
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_976PI3K Cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_121175PI Metabolism
REACT_75829PIP3 activates AKT signaling
REACT_798Platelet activation, signaling and aggregation
REACT_23787Regulation of signaling by CBL
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_160158Role of phospholipids in phagocytosis
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_121141Signaling by FGFR1 fusion mutants
REACT_120999Signaling by FGFR1 mutants
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_121025Synthesis of PIPs at the plasma membrane
REACT_12526TCR signaling
REACT_12621Tie2 Signaling
REACT_264464VEGFA-VEGFR2 Pathway
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
SMP00582Joubert syndrome
SMP00463Phosphatidylinositol Phosphate Metabolism
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