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MGP002299

Record overview

MGPD IDMGP002299
Gene ID5305
SpeciesHomo sapiens (Human)
Gene Namephosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Gene Symbol PIP4K2A
SynonymsPIPK; PI5P4KA; PIP5K2A; PIP5KIIA; PIP5KII-alpha;
Alternate namesphosphatidylinositol 5-phosphate 4-kinase type-2 alpha; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-4-phosphate-5-kinase; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; PI(5)P 4-kinase type II alpha; PIP4KII-alpha; PIP5KIII; PIP5KIIalpha; PtdIns(4)P-5-kinase B isoform; diphosphoinositide kinase 2-alpha; phosphatidylinositol 5-phosphate 4-kinase type II alpha; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha; phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; ptdIns(4)P-5-kinase C isoform; ptdIns(5)P-4-kinase isoform 2-alpha; type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform;
Chromosome10
Map Location10p12.2
EC Number2.7.1.149
SummaryPhosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PIP4K2A

Proteins

phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Refseq ID:NP_005019
Protein GI:6857820
UniProt ID:P48426
mRNA ID:NM_005028
Length:406
RefSeq Status:
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRN
LRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVF
SHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEE
EGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDF
IGHILT
 
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