MGP Database

MGP002303

Ontology/Pathway Information

Entrez Gene ID	5313
Gene Name	pyruvate kinase, liver and RBC
Gene Symbol	PKLR
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0005524	IEA:UniProtKB-KW	F	ATP binding
GO:0000287	IEA:InterPro	F	magnesium ion binding
GO:0030955	IEA:InterPro	F	potassium ion binding
GO:0004743	NAS:UniProtKB	F	pyruvate kinase activity
GO:0006754	IEA:Ensembl	P	ATP biosynthetic process
GO:0005975	TAS:Reactome	P	carbohydrate metabolic process
GO:0032869	IEA:Ensembl	P	cellular response to insulin stimulus
GO:0031018	TAS:Reactome	P	endocrine pancreas development
GO:0006112	TAS:Reactome	P	energy reserve metabolic process
GO:0006006	TAS:Reactome	P	glucose metabolic process
GO:0006096	TAS:Reactome	P	glycolytic process
GO:0031325	TAS:Reactome	P	positive regulation of cellular metabolic process
GO:0042866	IEA:Ensembl	P	pyruvate biosynthetic process
GO:0033198	IEA:Ensembl	P	response to ATP
GO:0051591	IEA:Ensembl	P	response to cAMP
GO:0009749	IEA:Ensembl	P	response to glucose
GO:0009408	IEA:Ensembl	P	response to heat
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0010226	IEA:Ensembl	P	response to lithium ion
GO:0007584	IEA:Ensembl	P	response to nutrient
GO:0051707	IEA:Ensembl	P	response to other organism
GO:0044281	TAS:Reactome	P	small molecule metabolic process

SMP Pathway Links

SMP ID	Description
SMP00572	Fanconi-bickel syndrome
SMP00531	Glycogenosis, Type VII. Tarui disease
SMP00040	Glycolysis
SMP00196	Leigh Syndrome
SMP00558	Primary hyperoxaluria II, PH2
SMP00334	Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
SMP00212	Pyruvate Dehydrogenase Complex Deficiency
SMP00559	Pyruvate kinase deficiency
SMP00060	Pyruvate Metabolism
SMP00654	Warburg Effect