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MGP002311

Record overview

MGPD IDMGP002311
Gene ID5328
SpeciesHomo sapiens (Human)
Gene Nameplasminogen activator, urokinase
Gene Symbol PLAU
SynonymsATF; QPD; UPA; URK; u-PA; BDPLT5;
Alternate namesurokinase-type plasminogen activator; U-plasminogen activator; plasminogen activator, urinary;
Chromosome10
Map Location10q22.2
EC Number3.4.21.73
SummaryThis gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
OrthologsView orthologs and multiple alignments for PLAU

Proteins

urokinase-type plasminogen activator isoform 1 preproprotein
Refseq ID:NP_002649
Protein GI:4505863
UniProt ID:P00749
mRNA ID:NM_002658
Length:431
RefSeq Status:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVL
QQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRH
RGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGC
ALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MRALLARLLLCVLVVSDSKG

mat_peptide: 21..177
product: plasminogen activator, urokinase isoform 1 long chain A
calculated_mol_wt: 17833
peptide sequence: 
SNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRF

mat_peptide: 156..177
product: plasminogen activator, urokinase isoform 1 short chain A
calculated_mol_wt: 2574
peptide sequence: 
KPSSPPEELKFQCGQKTLRPRF

mat_peptide: 179..431
product: plasminogen activator, urokinase isoform 1 chain B
calculated_mol_wt: 28425
peptide sequence: 
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
 
urokinase-type plasminogen activator isoform 2
Refseq ID:NP_001138503
Protein GI:222537759
UniProt ID:P00749
mRNA ID:NM_001145031
Length:414
RefSeq Status:
MVFHLRTRYEQANCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLG
KHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPC
WVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITG
FGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLP
WIRSHTKEENGLAL
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2158
peptide sequence: 
MRALLARLLLCVLVVSDSKG

mat_peptide: 21..177
product: plasminogen activator, urokinase isoform 1 long chain A
calculated_mol_wt: 17833
peptide sequence: 
SNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRF

mat_peptide: 156..177
product: plasminogen activator, urokinase isoform 1 short chain A
calculated_mol_wt: 2574
peptide sequence: 
KPSSPPEELKFQCGQKTLRPRF

mat_peptide: 179..431
product: plasminogen activator, urokinase isoform 1 chain B
calculated_mol_wt: 28425
peptide sequence: 
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
 
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