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MGP002312

UniProt Annotations

Entry Information
Gene Nameplasminogen activator, urokinase receptor
Protein EntryUPAR_HUMAN
UniProt IDQ03405
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; Synonyms=uPAR1, GPI-anchored; IsoId=Q03405-1; Sequence=Displayed; Name=2; Synonyms=uPAR2, Secreted; IsoId=Q03405-2; Sequence=VSP_006715; Name=3; IsoId=Q03405-3; Sequence=VSP_046345, VSP_046346; Note=Ref.3 (no nucleotide entry) sequence is in conflict in position: 158:V->I. {ECO:0000305};
FunctionActs as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
SimilarityContains 3 UPAR/Ly6 domains. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:12376466}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269|PubMed:12376466}.
Subcellular LocationIsoform 1: Cell membrane; Lipid-anchor, GPI- anchor.
Subcellular LocationIsoform 2: Secreted {ECO:0000305}.
SubunitMonomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with SORL1. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane. {ECO:0000269|PubMed:10636902, ECO:0000269|PubMed:12376466, ECO:0000269|PubMed:14764453, ECO:0000269|PubMed:15861141, ECO:0000269|PubMed:16456079, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:22285761, ECO:0000305}.
Tissue SpecificityExpressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLAURID41741ch19q13.html";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/plaur/";
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