MGP Database

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MGP002314

Ontology/Pathway Information

Entrez Gene ID5331
Gene Namephospholipase C, beta 3 (phosphatidylinositol-specific)
Gene Symbol PLCB3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0016020 IEA:UniProtKB-SubCellCmembrane
GO:0005654 IDA:HPACnucleoplasm
GO:0043234 IDA:MGICprotein complex
GO:0005509 IEA:InterProFcalcium ion binding
GO:0005516 IPI:BHF-UCLFcalmodulin binding
GO:0004435 IEA:UniProtKB-ECFphosphatidylinositol phospholipase C activity
GO:0004629 TAS:ProtIncFphospholipase C activity
GO:0004871 IEA:UniProtKB-KWFsignal transducer activity
GO:0043647 TAS:ReactomePinositol phosphate metabolic process
GO:0035556 IEA:InterProPintracellular signal transduction
GO:0016042 IEA:UniProtKB-KWPlipid catabolic process
GO:0003073 IDA:MGIPregulation of systemic arterial blood pressure
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007268 TAS:ReactomePsynaptic transmission
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18405Acetylcholine regulates insulin secretion
REACT_21312Activation of Kainate Receptors upon glutamate binding
REACT_264224beta-catenin independent WNT signaling
REACT_263982Ca2+ pathway
REACT_19193Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
REACT_19375Free fatty acids regulate insulin secretion
REACT_18283G alpha (q) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_19145G beta:gamma signalling through PLC beta
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_15526G-protein mediated events
REACT_150154Inositol phosphate metabolism
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15295Opioid Signalling
REACT_15426PLC beta mediated events
REACT_21254Presynaptic function of Kainate receptors
REACT_18325Regulation of insulin secretion
REACT_14797Signaling by GPCR
REACT_11045Signaling by Wnt
REACT_111102Signal Transduction
REACT_150312Synthesis of IP3 and IP4 in the cytosol
REACT_13477Transmission across Chemical Synapses
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