MGP Database

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MGP002317

Ontology/Pathway Information

Entrez Gene ID5335
Gene Namephospholipase C, gamma 1
Gene Symbol PLCG1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0042995 IDA:BHF-UCLCcell projection
GO:0008180 IDA:UniProtKBCCOP9 signalosome
GO:0005737 IDA:MGICcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0030027 IDA:UniProtKBClamellipodium
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0001726 IDA:UniProtKBCruffle
GO:0005509 IEA:InterProFcalcium ion binding
GO:0005168 IPI:UniProtKBFneurotrophin TRKA receptor binding
GO:0004435 IDA:UniProtKBFphosphatidylinositol phospholipase C activity
GO:0004629 TAS:ReactomeFphospholipase C activity
GO:0019901 IPI:BHF-UCLFprotein kinase binding
GO:0005057 NAS:UniProtKBFreceptor signaling protein activity
GO:0000186 TAS:ReactomePactivation of MAPKK activity
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0007411 TAS:ReactomePaxon guidance
GO:0007596 TAS:ReactomePblood coagulation
GO:0019722 IMP:BHF-UCLPcalcium-mediated signaling
GO:0016477 IMP:BHF-UCLPcell migration
GO:0071364 IDA:UniProtKBPcellular response to epidermal growth factor stimulus
GO:0019221 TAS:ReactomePcytokine-mediated signaling pathway
GO:0007173 IMP:BHF-UCLPepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0043647 TAS:ReactomePinositol phosphate metabolic process
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0050900 TAS:ReactomePleukocyte migration
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0009395 IEA:InterProPphospholipid catabolic process
GO:0045766 IDA:DFLATPpositive regulation of angiogenesis
GO:0043536 IDA:DFLATPpositive regulation of blood vessel endothelial cell migration
GO:0010634 IMP:UniProtKBPpositive regulation of epithelial cell migration
GO:0051281 IMP:BHF-UCLPpositive regulation of release of sequestered calcium ion into cytosol
GO:0007165 NAS:UniProtKBPsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0050852 TAS:ReactomePT cell receptor signaling pathway
GO:0016032 IEA:UniProtKB-KWPviral process
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_115676Antiviral mechanism by IFN-stimulated genes
REACT_18266Axon guidance
REACT_12051Cell surface interactions at the vascular wall
REACT_267817Constitutive Signaling by EGFRvIII
REACT_115852Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
REACT_75790Cytokine Signaling in Immune system
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_163701FCERI mediated MAPK activation
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_12076Frs2-mediated activation
REACT_12623Generation of second messenger molecules
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_150154Inositol phosphate metabolism
REACT_25229Interferon Signaling
REACT_115831ISG15 antiviral mechanism
REACT_111217Metabolism
REACT_22237Netrin-1 signaling
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12519PECAM1 interactions
REACT_21310Phospholipase C-mediated cascade
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_12005Prolonged ERK activation events
REACT_160158Role of phospholipids in phagocytosis
REACT_22228Role of second messengers in netrin-1 signaling
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_9470Signaling by FGFR
REACT_121141Signaling by FGFR1 fusion mutants
REACT_120999Signaling by FGFR1 mutants
REACT_120736Signaling by FGFR in disease
REACT_121398Signaling by FGFR mutants
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_111102Signal Transduction
REACT_150312Synthesis of IP3 and IP4 in the cytosol
REACT_12526TCR signaling
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
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