MGP Database

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MGP002318

Ontology/Pathway Information

Entrez Gene ID5336
Gene Namephospholipase C, gamma 2 (phosphatidylinositol-specific)
Gene Symbol PLCG2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0004435 IDA:UniProtKBFphosphatidylinositol phospholipase C activity
GO:0004629 TAS:ReactomeFphospholipase C activity
GO:0004871 IEA:UniProtKB-KWFsignal transducer activity
GO:0030183 ISS:UniProtKBPB cell differentiation
GO:0050853 ISS:UniProtKBPB cell receptor signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0019722 NAS:UniProtKBPcalcium-mediated signaling
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0038096 TAS:ReactomePFc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 TAS:ReactomePinnate immune response
GO:0043647 TAS:ReactomePinositol phosphate metabolic process
GO:0006661 IDA:UniProtKBPphosphatidylinositol biosynthetic process
GO:0009395 IEA:InterProPphospholipid catabolic process
GO:0030168 TAS:ReactomePplatelet activation
GO:0051209 IDA:UniProtKBPrelease of sequestered calcium ion into cytosol
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0050852 ISS:UniProtKBPT cell receptor signaling pathway
GO:0016055 TAS:UniProtKBPWnt signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_75774Adaptive Immune System
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_163701FCERI mediated MAPK activation
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_150154Inositol phosphate metabolism
REACT_111217Metabolism
REACT_798Platelet activation, signaling and aggregation
REACT_160158Role of phospholipids in phagocytosis
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_150312Synthesis of IP3 and IP4 in the cytosol
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_6966Toll-Like Receptors Cascades
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