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MGP002320

UniProt Annotations

Entry Information
Gene Namephospholipase D2
Protein EntryPLD2_HUMAN
UniProt IDO14939
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=PLD2A; IsoId=O14939-1; Sequence=Displayed; Name=PLD2C; IsoId=O14939-3; Sequence=VSP_005027; Name=PLD2B; IsoId=O14939-4; Sequence=VSP_054769;
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
Enzyme RegulationStimulated by phosphatidylinositol 4,5- bisphosphate and activated by the ADP-ribosylation factor-1 (ARF- 1).
FunctionMay have a role in signal-induced cytoskeletal regulation and/or endocytosis. {ECO:0000250}.
InteractionP23528:CFL1; NbExp=2; IntAct=EBI-1053996, EBI-352733; P62993:GRB2; NbExp=4; IntAct=EBI-1053996, EBI-401755;
PtmPhosphorylated by FGR. {ECO:0000250}.
SimilarityBelongs to the phospholipase D family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000305}.
SimilarityContains 1 PX (phox homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00147}.
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
Subcellular LocationMembrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
SubunitInteracts with EGFR (By similarity). Interacts with PIP5K1B. {ECO:0000250, ECO:0000269|PubMed:11032811}.
Tissue SpecificityUbiquitous.
Web ResourceName=Wikipedia; Note=Phospholipase D entry; URL="http://en.wikipedia.org/wiki/Phospholipase_D";
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