MGP Database

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MGP002322

Ontology/Pathway Information

Entrez Gene ID5340
Gene Nameplasminogen
Gene Symbol PLG
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0072562 IDA:UniProtKBCblood microparticle
GO:0009986 IDA:BHF-UCLCcell surface
GO:0005576 TAS:ReactomeCextracellular region
GO:0005615 IDA:UniProtKBCextracellular space
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031232 IDA:BHF-UCLCextrinsic component of external side of plasma membrane
GO:0005886 TAS:ReactomeCplasma membrane
GO:0031093 TAS:ReactomeCplatelet alpha granule lumen
GO:0034185 IPI:BHF-UCLFapolipoprotein binding
GO:0019904 IPI:UniProtKBFprotein domain specific binding
GO:0005102 IPI:AgBaseFreceptor binding
GO:0004252 IDA:BHF-UCLFserine-type endopeptidase activity
GO:0008236 TAS:AgBaseFserine-type peptidase activity
GO:0007596 IMP:HGNCPblood coagulation
GO:0044267 TAS:ReactomePcellular protein metabolic process
GO:0022617 IDA:BHF-UCLPextracellular matrix disassembly
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0042730 TAS:ReactomePfibrinolysis
GO:2000048 TAS:BHF-UCLPnegative regulation of cell-cell adhesion mediated by cadherin
GO:0008285 TAS:ProtIncPnegative regulation of cell proliferation
GO:0010812 IDA:BHF-UCLPnegative regulation of cell-substrate adhesion
GO:0051918 IDA:BHF-UCLPnegative regulation of fibrinolysis
GO:0030168 TAS:ReactomePplatelet activation
GO:0002576 TAS:ReactomePplatelet degranulation
GO:0051919 IDA:BHF-UCLPpositive regulation of fibrinolysis
GO:0048771 IEA:UniProtKB-KWPtissue remodeling
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_118682Activation of Matrix Metalloproteinases
REACT_118572Degradation of the extracellular matrix
REACT_641Dissolution of Fibrin Clot
REACT_118779Extracellular matrix organization
REACT_604Hemostasis
REACT_17015Metabolism of proteins
REACT_268444Orphan transporters
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_15428Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_16888Signaling by PDGF
REACT_111102Signal Transduction
REACT_15518Transmembrane transport of small molecules
SMP Pathway Links
SMP IDDescription
SMP00269Acenocoumarol Action Pathway
SMP00280Alteplase Action Pathway
SMP00286Aminocaproic Acid Action Pathway
SMP00281Anistreplase Action Pathway
SMP00288Aprotinin Action Pathway
SMP00275Ardeparin Action Pathway
SMP00276Argatroban Action Pathway
SMP00277Bivalirudin Action Pathway
SMP00586Coagulation
SMP00656Dicoumarol Action Pathway
SMP00270Dicumarol Action Pathway
SMP00272Enoxaparin Action Pathway
SMP00273Fondaparinux Action Pathway
SMP00274Heparin Action Pathway
SMP00278Lepirudin Action Pathway
SMP00655Phenindione Action Pathway
SMP00271Phenprocoumon Action Pathway
SMP00285Reteplase Action Pathway
SMP00282Streptokinase Action Pathway
SMP00283Tenecteplase Action Pathway
SMP00287Tranexamic Acid Action Pathway
SMP00284Urokinase Action Pathway
SMP00268Warfarin Action Pathway
SMP00279Ximelagatran Action Pathway
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