MGP Database

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MGP002326

Ontology/Pathway Information

Entrez Gene ID5347
Gene Namepolo-like kinase 1
Gene Symbol PLK1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:UniProtKBCcentrosome
GO:0000942 IDA:BHF-UCLCcondensed nuclear chromosome outer kinetochore
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:ReactomeCcytosol
GO:0000776 IDA:UniProtKBCkinetochore
GO:0015630 IDA:BHF-UCLCmicrotubule cytoskeleton
GO:0030496 IDA:UniProtKBCmidbody
GO:0005730 IDA:HPACnucleolus
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005819 IDA:UniProtKBCspindle
GO:0051233 IDA:UniProtKBCspindle midzone
GO:0000922 IDA:BHF-UCLCspindle pole
GO:0010997 IPI:UniProtKBFanaphase-promoting complex binding
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0016301 TAS:ReactomeFkinase activity
GO:0008017 IDA:UniProtKBFmicrotubule binding
GO:0004672 IDA:UniProtKBFprotein kinase activity
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0007092 IDA:UniProtKBPactivation of mitotic anaphase-promoting complex activity
GO:0031145 TAS:ReactomePanaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0008283 TAS:ProtIncPcell proliferation
GO:0051297 IMP:UniProtKBPcentrosome organization
GO:0000910 IDA:UniProtKBPcytokinesis
GO:0045184 IMP:MGIPestablishment of protein localization
GO:0031572 IDA:UniProtKBPG2 DNA damage checkpoint
GO:0000086 IDA:UniProtKBPG2/M transition of mitotic cell cycle
GO:0007091 TAS:ReactomePmetaphase/anaphase transition of mitotic cell cycle
GO:0001578 IDA:UniProtKBPmicrotubule bundle formation
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0000281 IDA:UniProtKBPmitotic cytokinesis
GO:0007067 IDA:UniProtKBPmitotic nuclear division
GO:0007077 TAS:ReactomePmitotic nuclear envelope disassembly
GO:0000070 IMP:UniProtKBPmitotic sister chromatid segregation
GO:0007094 IMP:UniProtKBPmitotic spindle assembly checkpoint
GO:0043066 IMP:UniProtKBPnegative regulation of apoptotic process
GO:0045736 IMP:BHF-UCLPnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000122 IMP:UniProtKBPnegative regulation of transcription from RNA polymerase II promoter
GO:0018105 IDA:UniProtKBPpeptidyl-serine phosphorylation
GO:0040038 IEA:EnsemblPpolar body extrusion after meiotic divisions
GO:0010800 IMP:BHF-UCLPpositive regulation of peptidyl-threonine phosphorylation
GO:0032436 IMP:UniProtKBPpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045862 IDA:UniProtKBPpositive regulation of proteolysis
GO:0051437 TAS:ReactomePpositive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051443 IMP:UniProtKBPpositive regulation of ubiquitin-protein transferase activity
GO:0031648 IDA:UniProtKBPprotein destabilization
GO:0071168 IDA:UniProtKBPprotein localization to chromatin
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0016567 IDA:UniProtKBPprotein ubiquitination
GO:0051726 TAS:ReactomePregulation of cell cycle
GO:0007346 IMP:UniProtKBPregulation of mitotic cell cycle
GO:0030071 IMP:BHF-UCLPregulation of mitotic metaphase/anaphase transition
GO:0043393 IMP:BHF-UCLPregulation of protein binding
GO:0051439 TAS:ReactomePregulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0046677 IEA:EnsemblPresponse to antibiotic
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6954Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
REACT_160122Activation of NIMA Kinases NEK9, NEK6, NEK7
REACT_267965Anchoring of the basal body to the plasma membrane
REACT_6761APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
REACT_6828APC/C-mediated degradation of cell cycle proteins
REACT_268265Assembly of the primary cilium
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_15479Centrosome maturation
REACT_264303Condensation of Prophase Chromosomes
REACT_1857Cyclin A/B1 associated events during G2/M transition
REACT_2203G2/M Transition
REACT_1100Golgi Cisternae Pericentriolar Stack Reorganization
REACT_15364Loss of Nlp from mitotic centrosomes
REACT_15451Loss of proteins required for interphase microtubule organization from the centrosome
REACT_1275Mitotic Anaphase
REACT_21391Mitotic G2-G2/M phases
REACT_1016Mitotic Metaphase/Anaphase Transition
REACT_150314Mitotic Metaphase and Anaphase
REACT_682Mitotic Prometaphase
REACT_765Mitotic Prophase
REACT_1932Mitotic Telophase/Cytokinesis
REACT_910M Phase
REACT_160255Nuclear Envelope Breakdown
REACT_264135Organelle biogenesis and maintenance
REACT_6875Phosphorylation of Emi1
REACT_6904Phosphorylation of the APC/C
REACT_1006Polo-like kinase mediated events
REACT_15296Recruitment of mitotic centrosome proteins and complexes
REACT_6837Regulation of APC/C activators between G1/S and early anaphase
REACT_21279Regulation of mitotic cell cycle
REACT_160315Regulation of PLK1 Activity at G2/M Transition
REACT_150425Resolution of Sister Chromatid Cohesion
REACT_150471Separation of Sister Chromatids
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