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MGP002333

UniProt Annotations

Entry Information
Gene Nameplexin A1
Protein EntryPLXA1_HUMAN
UniProt IDQ9UIW2
SpeciesHuman
Comments
Comment typeDescription
FunctionCoreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.
SimilarityBelongs to the plexin family. {ECO:0000305}.
SimilarityContains 1 Sema domain. {ECO:0000255|PROSITE- ProRule:PRU00352}.
SimilarityContains 4 IPT/TIG domains. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000250}.
SubunitInteracts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity). {ECO:0000250}.
Tissue SpecificityDetected in fetal brain, lung, liver and kidney. {ECO:0000269|PubMed:8570614}.
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