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MGP002348

UniProt Annotations

Entry Information
Gene Namephenylethanolamine N-methyltransferase
Protein EntryPNMT_HUMAN
UniProt IDP11086
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=99 uM for phenylethanolamine {ECO:0000269|PubMed:16363801}; KM=3.4 uM for S-adenosyl-L-methionine {ECO:0000269|PubMed:16363801};
Catalytic ActivityS-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine.
FunctionConverts noradrenaline to adrenaline.
PathwayCatecholamine biosynthesis; (R)-adrenaline biosynthesis; (R)-adrenaline from (R)-noradrenaline: step 1/1.
SimilarityBelongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. {ECO:0000305}.
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