MGP Database

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MGP002353

Ontology/Pathway Information

Entrez Gene ID5426
Gene Namepolymerase (DNA directed), epsilon, catalytic subunit
Gene Symbol POLE
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:HPACcytoplasm
GO:0008622 IDA:UniProtKBCepsilon DNA polymerase complex
GO:0005654 IDA:HPACnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:HPACplasma membrane
GO:0051539 IEA:UniProtKB-KWF4 iron, 4 sulfur cluster binding
GO:0003682 IDA:UniProtKBFchromatin binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0003887 IMP:UniProtKBFDNA-directed DNA polymerase activity
GO:0000166 IEA:InterProFnucleotide binding
GO:0008270 IEA:InterProFzinc ion binding
GO:0006287 IDA:UniProtKBPbase-excision repair, gap-filling
GO:0006281 TAS:ReactomePDNA repair
GO:0006260 IMP:UniProtKBPDNA replication
GO:0006270 TAS:ReactomePDNA replication initiation
GO:0000731 IMP:UniProtKBPDNA synthesis involved in DNA repair
GO:0000082 IMP:UniProtKBPG1/S transition of mitotic cell cycle
GO:0001701 IEA:EnsemblPin utero embryonic development
GO:0000278 TAS:ReactomePmitotic cell cycle
GO:0006289 TAS:ReactomePnucleotide-excision repair
GO:0006297 IMP:UniProtKBPnucleotide-excision repair, DNA gap filling
GO:0000723 TAS:ReactomePtelomere maintenance
GO:0000722 TAS:ReactomePtelomere maintenance via recombination
GO:0032201 TAS:ReactomePtelomere maintenance via semi-conservative replication
GO:0006283 TAS:ReactomePtranscription-coupled nucleotide-excision repair
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1095Activation of the pre-replicative complex
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_22172Chromosome Maintenance
REACT_216DNA Repair
REACT_383DNA Replication
REACT_2244DNA replication initiation
REACT_734DNA Replication Pre-Initiation
REACT_8030Extension of Telomeres
REACT_1783G1/S Transition
REACT_1998Gap-filling DNA repair synthesis and ligation in GG-NER
REACT_74Gap-filling DNA repair synthesis and ligation in TC-NER
REACT_2253Global Genomic NER (GG-NER)
REACT_1725M/G1 Transition
REACT_21267Mitotic G1-G1/S phases
REACT_1826Nucleotide Excision Repair
REACT_1993Repair synthesis for gap-filling by DNA polymerase in TC-NER
REACT_378Repair synthesis of patch ~27-30 bases long by DNA polymerase
REACT_899S Phase
REACT_2014Synthesis of DNA
REACT_7961Telomere C-strand (Lagging Strand) Synthesis
REACT_7993Telomere C-strand synthesis initiation
REACT_7970Telomere Maintenance
REACT_1628Transcription-coupled NER (TC-NER)
SMP Pathway Links
SMP IDDescription
SMP00478Nucleotide Excision Repair
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