MGP Database

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MGP002377

Ontology/Pathway Information

Entrez Gene ID5468
Gene Nameperoxisome proliferator-activated receptor gamma
Gene Symbol PPARG
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 ISS:BHF-UCLCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0090575 IDA:BHF-UCLCRNA polymerase II transcription factor complex
GO:0033613 IDA:BHF-UCLFactivating transcription factor binding
GO:0051393 IPI:UniProtKBFalpha-actinin binding
GO:0050544 ISS:BHF-UCLFarachidonic acid binding
GO:0003682 ISS:UniProtKBFchromatin binding
GO:0003677 IDA:UniProtKBFDNA binding
GO:0008144 IDA:BHF-UCLFdrug binding
GO:0019899 IPI:UniProtKBFenzyme binding
GO:0004879 IDA:BHF-UCLFligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0030374 IDA:UniProtKBFligand-dependent nuclear receptor transcription coactivator activity
GO:0004955 TAS:BHF-UCLFprostaglandin receptor activity
GO:0046965 IDA:BHF-UCLFretinoid X receptor binding
GO:0001012 IEA:EnsemblFRNA polymerase II regulatory region DNA binding
GO:0001228 IEA:EnsemblFRNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0043565 IEA:InterProFsequence-specific DNA binding
GO:0003700 IDA:BHF-UCLFsequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterProFsteroid hormone receptor activity
GO:0044212 IDA:BHF-UCLFtranscription regulatory region DNA binding
GO:0008270 IEA:InterProFzinc ion binding
GO:0006919 IDA:BHF-UCLPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050873 IEA:EnsemblPbrown fat cell differentiation
GO:0045165 ISS:BHF-UCLPcell fate commitment
GO:0048469 IDA:BHF-UCLPcell maturation
GO:0071455 IEA:EnsemblPcellular response to hyperoxia
GO:0032869 IMP:BHF-UCLPcellular response to insulin stimulus
GO:0071285 IEA:EnsemblPcellular response to lithium ion
GO:0071380 IEA:EnsemblPcellular response to prostaglandin E stimulus
GO:0071300 IEA:EnsemblPcellular response to retinoic acid
GO:0071306 IEA:EnsemblPcellular response to vitamin E
GO:0030855 ISS:BHF-UCLPepithelial cell differentiation
GO:0019395 IEA:EnsemblPfatty acid oxidation
GO:0010467 TAS:ReactomePgene expression
GO:0042593 IMP:BHF-UCLPglucose homeostasis
GO:0007186 TAS:GOCPG-protein coupled receptor signaling pathway
GO:0007507 IEA:EnsemblPheart development
GO:0045087 TAS:BHF-UCLPinnate immune response
GO:0055088 TAS:BHF-UCLPlipid homeostasis
GO:0006629 TAS:ProtIncPlipid metabolic process
GO:0042953 IDA:BHF-UCLPlipoprotein transport
GO:0015909 ISS:BHF-UCLPlong-chain fatty acid transport
GO:0045713 IDA:BHF-UCLPlow-density lipoprotein particle receptor biosynthetic process
GO:0030224 IDA:BHF-UCLPmonocyte differentiation
GO:0002674 IEA:EnsemblPnegative regulation of acute inflammatory response
GO:0030308 IEA:EnsemblPnegative regulation of cell growth
GO:0010887 IDA:BHF-UCLPnegative regulation of cholesterol storage
GO:0032966 IEA:EnsemblPnegative regulation of collagen biosynthetic process
GO:0060336 IMP:BHF-UCLPnegative regulation of interferon-gamma-mediated signaling pathway
GO:0010745 IDA:BHF-UCLPnegative regulation of macrophage derived foam cell differentiation
GO:2000230 IEA:EnsemblPnegative regulation of pancreatic stellate cell proliferation
GO:0010871 IDA:BHF-UCLPnegative regulation of receptor biosynthetic process
GO:0010891 IDA:BHF-UCLPnegative regulation of sequestering of triglyceride
GO:0048662 IDA:BHF-UCLPnegative regulation of smooth muscle cell proliferation
GO:0051974 IEA:EnsemblPnegative regulation of telomerase activity
GO:0045892 ISS:BHF-UCLPnegative regulation of transcription, DNA-templated
GO:0000122 IDA:BHF-UCLPnegative regulation of transcription from RNA polymerase II promoter
GO:0031100 IEA:EnsemblPorgan regeneration
GO:0035357 IMP:BHF-UCLPperoxisome proliferator activated receptor signaling pathway
GO:0001890 ISS:BHF-UCLPplacenta development
GO:0045600 ISS:HGNCPpositive regulation of fat cell differentiation
GO:0046321 IEA:EnsemblPpositive regulation of fatty acid oxidation
GO:0048714 IEA:EnsemblPpositive regulation of oligodendrocyte differentiation
GO:0060100 IEA:EnsemblPpositive regulation of phagocytosis, engulfment
GO:0051091 IDA:BHF-UCLPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0045893 ISS:BHF-UCLPpositive regulation of transcription, DNA-templated
GO:0045944 IDA:UniProtKBPpositive regulation of transcription from RNA polymerase II promoter
GO:0008217 IMP:BHF-UCLPregulation of blood pressure
GO:0060694 IC:BHF-UCLPregulation of cholesterol transporter activity
GO:0060850 ISS:UniProtKBPregulation of transcription involved in cell fate commitment
GO:0031000 IEA:EnsemblPresponse to caffeine
GO:0009409 IEA:EnsemblPresponse to cold
GO:0036270 IEA:EnsemblPresponse to diuretic
GO:0043627 IEA:EnsemblPresponse to estrogen
GO:0035902 IEA:EnsemblPresponse to immobilization stress
GO:0033993 ISS:BHF-UCLPresponse to lipid
GO:0055098 IDA:BHF-UCLPresponse to low-density lipoprotein particle
GO:0009612 IEA:EnsemblPresponse to mechanical stimulus
GO:1901558 IEA:EnsemblPresponse to metformin
GO:0007584 TAS:ProtIncPresponse to nutrient
GO:0032526 IDA:UniProtKBPresponse to retinoic acid
GO:0042594 IEA:EnsemblPresponse to starvation
GO:0033189 IEA:EnsemblPresponse to vitamin A
GO:0007165 IDA:BHF-UCLPsignal transduction
GO:0006367 TAS:ReactomePtranscription initiation from RNA polymerase II promoter
GO:0050872 TAS:UniProtKBPwhite fat cell differentiation
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_111045Developmental Biology
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_71Gene Expression
REACT_12627Generic Transcription Pathway
REACT_111217Metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_15525Nuclear Receptor transcription pathway
REACT_116145PPARA activates gene expression
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_27161Transcriptional regulation of white adipocyte differentiation
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