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MGP002384

Record overview

MGPD IDMGP002384
Gene ID5479
SpeciesHomo sapiens (Human)
Gene Namepeptidylprolyl isomerase B (cyclophilin B)
Gene Symbol PPIB
SynonymsOI9; CYPB; SCYLP; CYP-S1; HEL-S-39;
Alternate namespeptidyl-prolyl cis-trans isomerase B; PPIase B; S-cyclophilin; cyclophilin-like protein; epididymis secretory protein Li 39; rotamase B;
Chromosome15
Map Location15q21-q22
EC Number5.2.1.8
SummaryThe protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
OrthologsView orthologs and multiple alignments for PPIB

Proteins

peptidyl-prolyl cis-trans isomerase B precursor
Refseq ID:NP_000933
Protein GI:4758950
UniProt ID:P23284
mRNA ID:NM_000942
Length:216
RefSeq Status:
MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDF
MIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIA
DCGKIEVEKPFAIAKE
 
sig_peptide: 1..25
calculated_mol_wt: 2764
peptide sequence: 
MLRLSERNMKVLLAAALIAGSVFFL

mat_peptide: 26..216
product: peptidyl-prolyl cis-trans isomerase B
calculated_mol_wt: 20996
peptide sequence: 
LLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPD
ENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
 
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