MGP Database

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MGP002391

UniProt Annotations

Entry Information
Gene Nameprotein phosphatase 1, regulatory subunit 3C
Protein EntryPPR3C_HUMAN
UniProt IDQ9UQK1
SpeciesHuman
Comments
Comment typeDescription
DomainThe N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C- terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase. {ECO:0000250|UniProtKB:Q7TMB3}.
FunctionActs as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000250|UniProtKB:Q7TMB3, ECO:0000269|PubMed:8985175}.
InteractionO95278:EPM2A; NbExp=5; IntAct=EBI-2506727, EBI-2506661;
PtmUbiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner. {ECO:0000269|PubMed:18070875}.
Sequence CautionSequence=AAD33215.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityContains 1 CBM21 (carbohydrate binding type-21) domain. {ECO:0000255|PROSITE-ProRule:PRU00491}.
SubunitInteracts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. Also interacts with EPM2A/laforin. {ECO:0000250|UniProtKB:Q7TMB3, ECO:0000269|PubMed:14532330, ECO:0000269|PubMed:18070875, ECO:0000269|PubMed:8985175}.
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