MGP Database

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MGP002421

Ontology/Pathway Information

Entrez Gene ID5578
Gene Nameprotein kinase C, alpha
Gene Symbol PRKCA
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0045177 IEA:EnsemblCapical part of cell
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0030425 IEA:EnsemblCdendrite
GO:0005783 IDA:BHF-UCLCendoplasmic reticulum
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0031966 IEA:UniProtKB-SubCellCmitochondrial membrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0043025 IEA:EnsemblCneuronal cell body
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0048471 ISS:UniProtKBCperinuclear region of cytoplasm
GO:0001750 IEA:EnsemblCphotoreceptor outer segment
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004698 IEA:EnsemblFcalcium-dependent protein kinase C activity
GO:0019899 IDA:BHF-UCLFenzyme binding
GO:0035403 IDA:UniProtKBFhistone kinase activity (H3-T6 specific)
GO:0004672 IDA:UniProtKBFprotein kinase activity
GO:0004697 ISS:BHF-UCLFprotein kinase C activity
GO:0008270 IEA:InterProFzinc ion binding
GO:0007190 ISS:BHF-UCLPactivation of adenylate cyclase activity
GO:0007202 TAS:ReactomePactivation of phospholipase C activity
GO:0001525 IEA:UniProtKB-KWPangiogenesis
GO:0097190 TAS:ProtIncPapoptotic signaling pathway
GO:0007596 TAS:ReactomePblood coagulation
GO:0007155 IEA:UniProtKB-KWPcell adhesion
GO:0006874 IEA:EnsemblPcellular calcium ion homeostasis
GO:0071322 IEA:EnsemblPcellular response to carbohydrate stimulus
GO:0002062 IEA:EnsemblPchondrocyte differentiation
GO:0002159 IMP:BHF-UCLPdesmosome assembly
GO:0006112 TAS:ReactomePenergy reserve metabolic process
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0010467 TAS:ReactomePgene expression
GO:0035408 IDA:UniProtKBPhistone H3-T6 phosphorylation
GO:0000188 IEA:EnsemblPinactivation of MAPK activity
GO:0050930 IEA:EnsemblPinduction of positive chemotaxis
GO:0045087 TAS:ReactomePinnate immune response
GO:0097193 IEA:EnsemblPintrinsic apoptotic signaling pathway
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0007194 ISS:BHF-UCLPnegative regulation of adenylate cyclase activity
GO:0008285 IEA:EnsemblPnegative regulation of cell proliferation
GO:0034351 IMP:UniProtKBPnegative regulation of glial cell apoptotic process
GO:0046325 IEA:EnsemblPnegative regulation of glucose import
GO:0046627 IEA:EnsemblPnegative regulation of insulin receptor signaling pathway
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030593 IEA:EnsemblPneutrophil chemotaxis
GO:0036289 IEA:EnsemblPpeptidyl-serine autophosphorylation
GO:0007603 TAS:ReactomePphototransduction, visible light
GO:0030168 TAS:ReactomePplatelet activation
GO:0045766 IMP:UniProtKBPpositive regulation of angiogenesis
GO:0043536 IDA:DFLATPpositive regulation of blood vessel endothelial cell migration
GO:0010613 ISS:UniProtKBPpositive regulation of cardiac muscle hypertrophy
GO:0045785 IMP:UniProtKBPpositive regulation of cell adhesion
GO:0030335 IMP:UniProtKBPpositive regulation of cell migration
GO:2000707 ISS:UniProtKBPpositive regulation of dense core granule biogenesis
GO:0010595 IMP:UniProtKBPpositive regulation of endothelial cell migration
GO:0001938 IMP:UniProtKBPpositive regulation of endothelial cell proliferation
GO:0070374 ISS:UniProtKBPpositive regulation of ERK1 and ERK2 cascade
GO:0050729 IEA:EnsemblPpositive regulation of inflammatory response
GO:0031666 IMP:UniProtKBPpositive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045651 ISS:UniProtKBPpositive regulation of macrophage differentiation
GO:0045931 IMP:UniProtKBPpositive regulation of mitotic cell cycle
GO:0001934 IEA:EnsemblPpositive regulation of protein phosphorylation
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0050796 TAS:ReactomePregulation of insulin secretion
GO:0006937 IEA:EnsemblPregulation of muscle contraction
GO:0050730 IEA:EnsemblPregulation of peptidyl-tyrosine phosphorylation
GO:0090330 IDA:UniProtKBPregulation of platelet aggregation
GO:0022400 TAS:ReactomePregulation of rhodopsin mediated signaling pathway
GO:0002026 IEA:EnsemblPregulation of the force of heart contraction
GO:0070555 IMP:BHF-UCLPresponse to interleukin-1
GO:0016056 TAS:ReactomePrhodopsin mediated signaling pathway
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0007165 TAS:ReactomePsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0007268 TAS:ReactomePsynaptic transmission
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_18405Acetylcholine regulates insulin secretion
REACT_264224beta-catenin independent WNT signaling
REACT_263982Ca2+ pathway
REACT_15307Ca-dependent events
REACT_9000Calmodulin induced events
REACT_9053CaM pathway
REACT_115566Cell Cycle
REACT_152Cell Cycle, Mitotic
REACT_111064DAG and IP3 signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_263908Depolymerisation of the Nuclear Lamina
REACT_116125Disease
REACT_160102Diseases associated with visual transduction
REACT_1178Disinhibition of SNARE formation
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_121096EGFR Transactivation by Gastrin
REACT_118779Extracellular matrix organization
REACT_19333G alpha (z) signalling events
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_71Gene Expression
REACT_18347Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
REACT_19184GPCR downstream signaling
REACT_15526G-protein mediated events
REACT_604Hemostasis
REACT_25218HuR stabilizes mRNA
REACT_6900Immune System
REACT_163919Inactivation, recovery and regulation of the phototransduction cascade
REACT_6802Innate Immune System
REACT_1505Integration of energy metabolism
REACT_111217Metabolism
REACT_765Mitotic Prophase
REACT_910M Phase
REACT_13685Neuronal System
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_163874Non-integrin membrane-ECM interactions
REACT_160255Nuclear Envelope Breakdown
REACT_15295Opioid Signalling
REACT_264199PCP/CE pathway
REACT_21310Phospholipase C-mediated cascade
REACT_798Platelet activation, signaling and aggregation
REACT_15426PLC beta mediated events
REACT_115720PLCG1 events in ERBB2 signaling
REACT_12079PLC-gamma1 signalling
REACT_18325Regulation of insulin secretion
REACT_111225Regulation of KIT signaling
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_12529Signaling by VEGF
REACT_11045Signaling by Wnt
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_163942Syndecan interactions
REACT_163722The phototransduction cascade
REACT_18307Trafficking of AMPA receptors
REACT_18422Trafficking of GluR2-containing AMPA receptors
REACT_13477Transmission across Chemical Synapses
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
REACT_160125Visual phototransduction
REACT_263890WNT5A-dependent internalization of FZD4
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
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