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MGP002423

Record overview

MGPD IDMGP002423
Gene ID5580
SpeciesHomo sapiens (Human)
Gene Nameprotein kinase C, delta
Gene Symbol PRKCD
SynonymsMAY1; PKCD; ALPS3; CVID9; nPKC-delta;
Alternate namesprotein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD;
Chromosome3
Map Location3p21.31
EC Number2.7.11.13
SummaryProtein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PRKCD

Proteins

protein kinase C delta type
Refseq ID:NP_006245
Protein GI:31377782
UniProt ID:Q05655
mRNA ID:NM_006254
Length:676
RefSeq Status:
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNG
KAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKC
IDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRV
LTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIF
GESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED
 
protein kinase C delta type
Refseq ID:NP_997704
Protein GI:47157325
UniProt ID:Q05655
mRNA ID:NM_212539
Length:676
RefSeq Status:
Protein sequence is identical to GI:31377782 (mRNA isoform)
 
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