MGP Database

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MGP002438

Ontology/Pathway Information

Entrez Gene ID5599
Gene Namemitogen-activated protein kinase 8
Gene Symbol MAPK8
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:BHF-UCLCnucleus
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0042826 IPI:BHF-UCLFhistone deacetylase binding
GO:0035033 IMP:BHF-UCLFhistone deacetylase regulator activity
GO:0004705 IDA:UniProtKBFJUN kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0006915 TAS:ReactomePapoptotic process
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0070301 IEA:EnsemblPcellular response to hydrogen peroxide
GO:0071222 IDA:MGIPcellular response to lipopolysaccharide
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0071732 IEA:EnsemblPcellular response to nitric oxide
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0045087 TAS:ReactomePinnate immune response
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0007254 IDA:UniProtKBPJNK cascade
GO:0007258 IDA:UniProtKBPJUN phosphorylation
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0032091 IDA:UniProtKBPnegative regulation of protein binding
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0001503 IEA:EnsemblPossification
GO:0018105 IDA:UniProtKBPpeptidyl-serine phosphorylation
GO:0018107 IDA:UniProtKBPpeptidyl-threonine phosphorylation
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0090045 IMP:BHF-UCLPpositive regulation of deacetylase activity
GO:2000017 IEA:EnsemblPpositive regulation of determination of dorsal identity
GO:0010628 IMP:BHF-UCLPpositive regulation of gene expression
GO:1900740 TAS:ReactomePpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0097300 IEA:EnsemblPprogrammed necrotic cell death
GO:0031063 IMP:GOCPregulation of histone deacetylation
GO:0032880 IDA:BHF-UCLPregulation of protein localization
GO:0051090 TAS:ReactomePregulation of sequence-specific DNA binding transcription factor activity
GO:0046686 IEA:EnsemblPresponse to cadmium ion
GO:0006950 TAS:ProtIncPresponse to stress
GO:0009411 IDA:MGIPresponse to UV
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_697Activation of BH3-only proteins
REACT_1650Activation of BIM and translocation to mitochondria
REACT_2100Activation of BMF and translocation to mitochondria
REACT_21326Activation of the AP-1 family of transcription factors
REACT_578Apoptosis
REACT_111155Cell-Cell communication
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_25299DSCAM interactions
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_964Intrinsic Pathway for Apoptosis
REACT_21368JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REACT_21308MAP kinase activation in TLR cascade
REACT_21328MAPK targets/ Nuclear events mediated by MAP kinases
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_13638NRAGE signals death through JNK
REACT_13643NRIF signals cell death from the nucleus
REACT_169436Oxidative Stress Induced Senescence
REACT_13776p75 NTR receptor-mediated signalling
REACT_268456Programmed Cell Death
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
SMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
SMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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