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MGP002439

Record overview

MGPD IDMGP002439
Gene ID5600
SpeciesHomo sapiens (Human)
Gene Namemitogen-activated protein kinase 11
Gene Symbol MAPK11
SynonymsP38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2;
Alternate namesmitogen-activated protein kinase 11; MAP kinase 11; MAP kinase p38 beta; mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; stress-activated protein kinase-2; stress-activated protein kinase-2b;
Chromosome22
Map Location22q13.33
EC Number2.7.11.24
SummaryThis gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
OrthologsView orthologs and multiple alignments for MAPK11

Proteins

mitogen-activated protein kinase 11
Refseq ID:NP_002742
Protein GI:20128774
UniProt ID:Q15759
mRNA ID:NM_002751
Length:364
RefSeq Status:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFS
EVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHY
NQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ
 
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