MGP Database

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MGP002443

Ontology/Pathway Information

Entrez Gene ID5604
Gene Namemitogen-activated protein kinase kinase 1
Gene Symbol MAP2K1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0030424 IEA:EnsemblCaxon
GO:0005938 IEA:EnsemblCcell cortex
GO:0005737 IDA:HPACcytoplasm
GO:0005829 TAS:UniProtKBCcytosol
GO:0032839 IEA:EnsemblCdendrite cytoplasm
GO:0005769 TAS:UniProtKBCearly endosome
GO:0005783 IDA:MGICendoplasmic reticulum
GO:0070062 IDA:UniProtKBCextracellular vesicular exosome
GO:0005925 TAS:UniProtKBCfocal adhesion
GO:0005794 TAS:UniProtKBCGolgi apparatus
GO:0005770 TAS:UniProtKBClate endosome
GO:0005874 IEA:EnsemblCmicrotubule
GO:0005739 TAS:UniProtKBCmitochondrion
GO:0005634 TAS:UniProtKBCnucleus
GO:0043204 IEA:EnsemblCperikaryon
GO:0048471 IEA:EnsemblCperinuclear region of cytoplasm
GO:0005886 IDA:HPACplasma membrane
GO:0005816 IEA:UniProtKB-SubCellCspindle pole body
GO:0005524 IEA:UniProtKB-KWFATP binding
GO:0004708 IDA:UniProtKBFMAP kinase kinase activity
GO:0008022 IPI:MGIFprotein C-terminus binding
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0047485 IPI:MGIFprotein N-terminus binding
GO:0043539 IDA:UniProtKBFprotein serine/threonine kinase activator activity
GO:0004674 TAS:ReactomeFprotein serine/threonine kinase activity
GO:0004712 TAS:UniProtKBFprotein serine/threonine/tyrosine kinase activity
GO:0004713 IEA:UniProtKB-KWFprotein tyrosine kinase activity
GO:0004728 IEA:EnsemblFreceptor signaling protein tyrosine phosphatase activity
GO:0000187 TAS:UniProtKBPactivation of MAPK activity
GO:0000186 TAS:ReactomePactivation of MAPKK activity
GO:0007411 TAS:ReactomePaxon guidance
GO:0007050 IMP:BHF-UCLPcell cycle arrest
GO:0048870 IEA:EnsemblPcell motility
GO:0008283 IEA:EnsemblPcell proliferation
GO:0006928 TAS:ProtIncPcellular component movement
GO:0090398 IMP:BHF-UCLPcellular senescence
GO:0006935 TAS:ProtIncPchemotaxis
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0048313 IEA:EnsemblPGolgi inheritance
GO:0045087 TAS:ReactomePinnate immune response
GO:0008286 TAS:ReactomePinsulin receptor signaling pathway
GO:0030216 IEA:EnsemblPkeratinocyte differentiation
GO:0060711 IEA:EnsemblPlabyrinthine layer development
GO:0000165 TAS:ReactomePMAPK cascade
GO:0032402 IEA:EnsemblPmelanosome transport
GO:0007067 IEA:EnsemblPmitotic nuclear division
GO:0002755 TAS:ReactomePMyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS:ReactomePMyD88-independent toll-like receptor signaling pathway
GO:0008285 IDA:BHF-UCLPnegative regulation of cell proliferation
GO:0034111 IEA:EnsemblPnegative regulation of homotypic cell-cell adhesion
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0060674 IEA:EnsemblPplacenta blood vessel development
GO:0045597 IEA:EnsemblPpositive regulation of cell differentiation
GO:0030335 IEA:EnsemblPpositive regulation of cell migration
GO:0010628 IMP:UniProtKBPpositive regulation of gene expression
GO:0071902 IDA:UniProtKBPpositive regulation of protein serine/threonine kinase activity
GO:0032320 IEA:EnsemblPpositive regulation of Ras GTPase activity
GO:0046579 IEA:EnsemblPpositive regulation of Ras protein signal transduction
GO:0032968 IEA:EnsemblPpositive regulation of transcription elongation from RNA polymerase II promoter
GO:0051291 IEA:EnsemblPprotein heterooligomerization
GO:0007265 TAS:ReactomePRas protein signal transduction
GO:2000641 TAS:UniProtKBPregulation of early endosome to late endosome transport
GO:0090170 TAS:UniProtKBPregulation of Golgi inheritance
GO:0032872 TAS:UniProtKBPregulation of stress-activated MAPK cascade
GO:0003056 IEA:EnsemblPregulation of vascular smooth muscle contraction
GO:0048678 IEA:EnsemblPresponse to axon injury
GO:0051384 IEA:EnsemblPresponse to glucocorticoid
GO:0006979 IEA:EnsemblPresponse to oxidative stress
GO:0007165 TAS:ProtIncPsignal transduction
GO:0007264 TAS:ReactomePsmall GTPase mediated signal transduction
GO:0051403 TAS:ReactomePstress-activated MAPK cascade
GO:0034166 TAS:ReactomePtoll-like receptor 10 signaling pathway
GO:0034134 TAS:ReactomePtoll-like receptor 2 signaling pathway
GO:0034138 TAS:ReactomePtoll-like receptor 3 signaling pathway
GO:0034142 TAS:ReactomePtoll-like receptor 4 signaling pathway
GO:0034146 TAS:ReactomePtoll-like receptor 5 signaling pathway
GO:0034162 TAS:ReactomePtoll-like receptor 9 signaling pathway
GO:0002224 TAS:ReactomePtoll-like receptor signaling pathway
GO:0038123 TAS:ReactomePtoll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS:ReactomePtoll-like receptor TLR6:TLR2 signaling pathway
GO:0035666 TAS:ReactomePTRIF-dependent toll-like receptor signaling pathway
GO:0047496 IEA:EnsemblPvesicle transport along microtubule
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_6890Activated TLR4 signalling
REACT_12002ARMS-mediated activation
REACT_18266Axon guidance
REACT_75790Cytokine Signaling in Immune system
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_111045Developmental Biology
REACT_116125Disease
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_1391ERK1 activation
REACT_1482ERK activation
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163701FCERI mediated MAPK activation
REACT_12076Frs2-mediated activation
REACT_21247FRS2-mediated cascade
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_12606GRB2 events in EGFR signaling
REACT_115854GRB2 events in ERBB2 signaling
REACT_150210IGF1R signaling cascade
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_1195Insulin receptor signalling cascade
REACT_22442Interleukin-1 signaling
REACT_27283Interleukin-2 signaling
REACT_332IRS-mediated signalling
REACT_762IRS-related events
REACT_150203IRS-related events triggered by IGF1R
REACT_22205L1CAM interactions
REACT_21308MAP kinase activation in TLR cascade
REACT_962MEK activation
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_6809MyD88-independent cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_18334NCAM signaling for neurite out-growth
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12005Prolonged ERK activation events
REACT_634RAF/MAP kinase cascade
REACT_614RAF phosphorylates MEK
REACT_12579SHC1 events in EGFR signaling
REACT_115993SHC1 events in ERBB2 signaling
REACT_116005SHC1 events in ERBB4 signaling
REACT_661SHC-mediated signalling
REACT_999SHC-related events
REACT_150139SHC-related events triggered by IGF1R
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_268269Signaling by EGFRvIII in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_498Signaling by Insulin receptor
REACT_22232Signaling by Interleukins
REACT_169118Signaling by Leptin
REACT_268006Signaling by Ligand-Responsive EGFR Variants in Cancer
REACT_268546Signaling by Overexpressed Wild-Type EGFR in Cancer
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_12529Signaling by VEGF
REACT_11061Signalling by NGF
REACT_12058Signalling to ERKs
REACT_12077Signalling to p38 via RIT and RIN
REACT_12033Signalling to RAS
REACT_111102Signal Transduction
REACT_22272Signal transduction by L1
REACT_524SOS-mediated signalling
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6966Toll-Like Receptors Cascades
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_264041Uptake and actions of bacterial toxins
REACT_264618Uptake and function of anthrax toxins
REACT_264464VEGFA-VEGFR2 Pathway
REACT_264273VEGFR2 mediated cell proliferation
SMP Pathway Links
SMP IDDescription
SMP00358Fc Epsilon Receptor I Signaling in Mast Cells
SMP00391Insulin Signalling
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