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MGP002445

Record overview

MGPD IDMGP002445
Gene ID5606
SpeciesHomo sapiens (Human)
Gene Namemitogen-activated protein kinase kinase 3
Gene Symbol MAP2K3
SynonymsMEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2;
Alternate namesdual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK 3; MEK 3; SAPK kinase 2; stress-activated protein kinase kinase 2;
Chromosome17
Map Location17q11.2
EC Number2.7.12.2
SummaryThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MAP2K3

Proteins

dual specificity mitogen-activated protein kinase kinase 3 isoform A
Refseq ID:NP_002747
Protein GI:21618347
UniProt ID:P46734
mRNA ID:NM_002756
Length:318
RefSeq Status:
MSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGA
LFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKP
YMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK
TKKTDIAAFVKEILGEDS
 
dual specificity mitogen-activated protein kinase kinase 3 isoform B
Refseq ID:NP_659731
Protein GI:21618349
UniProt ID:P46734
mRNA ID:NM_145109
Length:347
RefSeq Status:
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVN
SQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINK
EGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
 
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