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MGP002448

Record overview

MGPD IDMGP002448
Gene ID5609
SpeciesHomo sapiens (Human)
Gene Namemitogen-activated protein kinase kinase 7
Gene Symbol MAP2K7
SynonymsMEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4;
Alternate namesdual specificity mitogen-activated protein kinase kinase 7; JNK-activating kinase 2; MAP kinase kinase 7; MAPK/ERK kinase 7; SAPK kinase 4; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4;
Chromosome19
Map Location19p13.3-p13.2
EC Number2.7.12.2
SummaryThe protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
OrthologsView orthologs and multiple alignments for MAP2K7

Proteins

dual specificity mitogen-activated protein kinase kinase 7 isoform 1
Refseq ID:NP_001284484
Protein GI:662033893
UniProt ID:O14733
mRNA ID:NM_001297555
Length:435
RefSeq Status:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPIIVITLSPAPAPSQRAALQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTP
RSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFG
TFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM
APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYE
TLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
 
dual specificity mitogen-activated protein kinase kinase 7 isoform 2
Refseq ID:NP_001284485
Protein GI:662033895
UniProt ID:O14733
mRNA ID:NM_001297556
Length:426
RefSeq Status:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIM
KQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMG
TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLPCPSPSQVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASW
FKDVMAKTESPRTSGVLSQPHLPFFR
 
dual specificity mitogen-activated protein kinase kinase 7 isoform 3
Refseq ID:NP_660186
Protein GI:21735544
UniProt ID:O14733
mRNA ID:NM_145185
Length:419
RefSeq Status:
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIM
KQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMG
TCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAK
TESPRTSGVLSQPHLPFFR
 
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